Corynebacterium glutamicum, Escherichia coli, and Saccharomyces cerevisiae in particular,
have become established as important industrial workhorses in biotechnology. Recent years …

Lithium has literally been everywhere forever, since it is one of the three elements created in
the Big Bang. Lithium concentration in rocks, soil, and fresh water is highly variable from …

Alcohol dehydrogenases (ADHs) constitute a large family of enzymes responsible for the
reversible oxidation of alcohols to aldehydes with the concomitant reduction of NAD+ or …

In contrast to batch cultivation, chemostat cultivation allows the identification of carbon
source responses without interference by carbon-catabolite repression, accumulation of …

Metabolic fluxes may be regulated “hierarchically,” eg, by changes of gene expression that
adjust enzyme capacities (V max) and/or “metabolically” by interactions of enzymes with …

Background Growth rate is central to the development of cells in all organisms. However,
little is known about the impact of changing growth rates. We used continuous cultures to …

The importance of regulatory control in metabolic processes is widely acknowledged, and
several enquiries (both local and global) are being made in understanding regulation at …

Background With the sequence of the Plasmodium falciparum genome and several global
mRNA and protein life cycle expression profiling projects now completed, elucidating the …

Saccharomyces cerevisiae is unique among yeasts in its ability to grow rapidly in the
complete absence of oxygen. S. cerevisiae is therefore an ideal eukaryotic model to study …

Since our last review in 2002, there have been significant changes in the field of proteomics.
The hype surrounding this field has diminished as it has matured. The initial and overly …