Recent advances in experimental dendritic cell vaccines for cancer

IY Filin, KV Kitaeva, CS Rutland, AA Rizvanov… - Frontiers in …, 2021 - frontiersin.org
The development of immunotherapeutic methods for the treatment of oncological diseases
have made it possible to improve the effectiveness of standard therapies. There was no …

The complex tumor microenvironment in ovarian cancer: therapeutic challenges and opportunities

B Garlisi, S Lauks, C Aitken, LM Ogilvie, C Lockington… - Current oncology, 2024 - mdpi.com
The tumor microenvironment (TME) in ovarian cancer (OC) has much greater complexity
than previously understood. In response to aggressive pro-angiogenic stimulus, blood …

Trial watch: Dendritic cell (DC)-based immunotherapy for cancer

RS Laureano, J Sprooten, I Vanmeerbeerk… - …, 2022 - Taylor & Francis
Dendritic cell (DC)-based vaccination for cancer treatment has seen considerable
development over recent decades. However, this field is currently in a state of flux toward …

Immunotherapy in ovarian cancer

N Siminiak, R Czepczyński, MP Zaborowski… - Archivum Immunologiae …, 2022 - Springer
Despite advances in surgery and chemotherapy, ovarian cancer remains one of the most
lethal malignancies. Hence, the implementation of novel treatment approaches is required to …

Integration of local and systemic immunity in ovarian cancer: Implications for immunotherapy

A Rajtak, M Ostrowska-Leśko, K Żak… - Frontiers in …, 2022 - frontiersin.org
Cancer is a disease that induces many local and systemic changes in immunity. The difficult
nature of ovarian cancer stems from the lack of characteristic symptoms that contributes to a …

[HTML][HTML] Relationship between Th17 immune response and cancer

HS Marques, BB de Brito, FAF da Silva… - World Journal of …, 2021 - ncbi.nlm.nih.gov
Cancer is the second leading cause of death worldwide and epidemiological projections
predict growing cancer mortality rates in the next decades. Cancer has a close relationship …

Dendritic cell vaccines: A promising approach in the fight against ovarian cancer

AA Caro, S Deschoemaeker, L Allonsius… - Cancers, 2022 - mdpi.com
Simple Summary With an overall 5-year survival of only 20% for advanced-stage ovarian
cancer patients, enduring and effective therapies are a highly unmet clinical need. Current …

Dendritic cells: the yin and yang in disease progression

C Jimenez-Cortegana, F Palomares, G Alba… - Frontiers in …, 2024 - frontiersin.org
Dendritic cells (DCs) are antigen presenting cells that link innate and adaptive immunity.
DCs have been historically considered as the most effective and potent cell population to …

Targeting the immune microenvironment for ovarian cancer therapy

F Blanc-Durand, L Clemence Wei Xian… - Frontiers in …, 2023 - frontiersin.org
Ovarian cancer (OC) is an aggressive malignancy characterized by a complex
immunosuppressive tumor microenvironment (TME). Immune checkpoint inhibitors have …

The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cells

ML Sánchez-León, C Jiménez-Cortegana… - Frontiers in …, 2022 - frontiersin.org
Dendritic cells (DCs) are a heterogenous population of professional antigen presenting cells
whose main role is diminished in a variety of malignancies, including cancer, leading to …