Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …

Fetal hemoglobin (HbF) can blunt the pathophysiology, temper the clinical course, and offer
prospects for curative therapy of sickle cell disease. This review focuses on (1) HbF …

Fetal hemoglobin (HbF) has well‐known tempering effects on the symptoms of sickle cell
disease and its levels vary among patients with different haplotypes of the sickle hemoglobin …

Introduction Sickle cell disease and β thalassemia are the principal β hemoglobinopathies.
The complex pathophysiology of sickle cell disease is initiated by sickle hemoglobin …

Hb F modulates sickle cell disease. Five major haplotypes of the β-globin gene cluster are
associated with sickle cell disease. In the Eastern Province of Saudi Arabia, the Arab-Indian …

Background: Sickle cell disease (SCD) is a monogenic disease that has wide variety of
phenotypes with both and environmental factors contributing to its severity. Methods: We …

Background and Objectives. β‐Thalassemia and sickle cell disease are genetic disorders
characterized by reduced and abnormal β‐globin chain production, respectively. The …

Introduction: Sickle cell anemia is a Mendelian disease that is noted for the heterogeneity of
its clinical expression. Because of this, providing an accurate prognosis has been a longtime …

Background and Objectives: Sickle cell anemia (SCA) is a hereditary monogenic disease
due to a single β-globin gene mutation that codes for the production of sickle hemoglobin. Its …

Disease severity of sickle cell anemia is highly variable, and it is commonly accepted that
fetal hemoglobin (HbF) levels play a major role as an ameliorating factor. Investigation of …