Cancer immunotherapy, mainly including immune checkpoints-targeted therapy and the
adoptive transfer of engineered immune cells, has revolutionized the oncology landscape as …

Gangliosides are glycosphingolipids highly abundant in the nervous system, and carry most
of the sialic acid residues in the brain. Gangliosides are enriched in cell membrane …

Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

Every cell in nature carries a rich surface coat of glycans, its glycocalyx, which constitutes
the cell's interface with its environment. In eukaryotes, the glycocalyx is composed of …

Sphingolipids are highly enriched in the nervous system where they are pivotal constituents
of the plasma membranes and are important for proper brain development and functions …

Gangliosides are sialic acid-containing glycosphingolipids that are most abundant in the
nervous system. Heterogeneity and diversity of the structures in their carbohydrate chains …

Glycosphingolipids (GSL s) comprise a heterogeneous group of membrane lipids formed by
a ceramide backbone covalently linked to a glycan moiety. Hundreds of different glycans …

▪ Abstract Researchers have long predicted that complex carbohydrates on cell surfaces
would play important roles in developmental processes because of the observation that …

Rapid conduction of nerve impulses requires coating of axons by myelin sheaths, which are
lipid-rich and multilamellar membrane stacks. The lipid composition of myelin varies …

GM1 ganglioside occurs widely in vertebrate tissues, where it exhibits many essential
functions, both in the plasma membrane and intracellular loci. Its essentiality is revealed in …