Normalizing function of tumor vessels: progress, opportunities, and challenges

JD Martin, G Seano, RK Jain - Annual review of physiology, 2019 - annualreviews.org
Abnormal blood and lymphatic vessels create a hostile tumor microenvironment
characterized by hypoxia, low pH, and elevated interstitial fluid pressure. These …

Receptor tyrosine kinases (RTKs) in breast cancer: signaling, therapeutic implications and challenges

R Butti, S Das, VP Gunasekaran, AS Yadav, D Kumar… - Molecular cancer, 2018 - Springer
Breast cancer is a multifactorial disease and driven by aberrant regulation of cell signaling
pathways due to the acquisition of genetic and epigenetic changes. An array of growth …

Trends and challenges in tumor anti-angiogenic therapies

J Jászai, MHH Schmidt - Cells, 2019 - mdpi.com
Excessive abnormal angiogenesis plays a pivotal role in tumor progression and is a
hallmark of solid tumors. This process is driven by an imbalance between pro-and anti …

Metabolic rewiring in the promotion of cancer metastasis: mechanisms and therapeutic implications

Q Wei, Y Qian, J Yu, CC Wong - Oncogene, 2020 - nature.com
Tumor metastasis is the major cause of mortality from cancer. Metabolic rewiring and the
metastatic cascade are highly intertwined, co-operating to promote multiple steps of cancer …

Obesity-induced inflammation and desmoplasia promote pancreatic cancer progression and resistance to chemotherapy

J Incio, H Liu, P Suboj, SM Chin, IX Chen, M Pinter… - Cancer discovery, 2016 - AACR
It remains unclear how obesity worsens treatment outcomes in patients with pancreatic
ductal adenocarcinoma (PDAC). In normal pancreas, obesity promotes inflammation and …

Cancer and inflammation

LL Munn - Wiley Interdisciplinary Reviews: Systems Biology …, 2017 - Wiley Online Library
The relationship between inflammation and cancer has been recognized since the 17th
century, 1 and we now know much about the cells, cytokines and physiological processes …

Role of VEGFs/VEGFR-1 signaling and its inhibition in modulating tumor invasion: experimental evidence in different metastatic cancer models

C Ceci, MG Atzori, PM Lacal, G Graziani - International journal of …, 2020 - mdpi.com
The vascular endothelial growth factor (VEGF) family members, VEGF-A, placenta growth
factor (PlGF), and to a lesser extent VEGF-B, play an essential role in tumor-associated …

[HTML][HTML] VEGFR1 signaling in retinal angiogenesis and microinflammation

A Uemura, M Fruttiger, PA d'Amore, S De Falco… - Progress in retinal and …, 2021 - Elsevier
Five vascular endothelial growth factor receptor (VEGFR) ligands (VEGF-A,-B,–C,-D, and
placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 …

Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2

J Incio, JA Ligibel, DT McManus, P Suboj… - Science translational …, 2018 - science.org
Anti–vascular endothelial growth factor (VEGF) therapy has failed to improve survival in
patients with breast cancer (BC). Potential mechanisms of resistance to anti-VEGF therapy …

Therapeutic implication of vascular endothelial growth factor receptor-1 (VEGFR-1) targeting in cancer cells and tumor microenvironment by competitive and non …

PM Lacal, G Graziani - Pharmacological research, 2018 - Elsevier
The vascular endothelial growth factor receptor-1 (VEGFR-1) is a tyrosine kinase receptor
for VEGF-A, VEGF-B, and placental growth factor (PlGF) ligands that is expressed in …