Normalizing function of tumor vessels: progress, opportunities, and challenges
Abnormal blood and lymphatic vessels create a hostile tumor microenvironment
characterized by hypoxia, low pH, and elevated interstitial fluid pressure. These …
characterized by hypoxia, low pH, and elevated interstitial fluid pressure. These …
Receptor tyrosine kinases (RTKs) in breast cancer: signaling, therapeutic implications and challenges
Breast cancer is a multifactorial disease and driven by aberrant regulation of cell signaling
pathways due to the acquisition of genetic and epigenetic changes. An array of growth …
pathways due to the acquisition of genetic and epigenetic changes. An array of growth …
Trends and challenges in tumor anti-angiogenic therapies
J Jászai, MHH Schmidt - Cells, 2019 - mdpi.com
Excessive abnormal angiogenesis plays a pivotal role in tumor progression and is a
hallmark of solid tumors. This process is driven by an imbalance between pro-and anti …
hallmark of solid tumors. This process is driven by an imbalance between pro-and anti …
Metabolic rewiring in the promotion of cancer metastasis: mechanisms and therapeutic implications
Tumor metastasis is the major cause of mortality from cancer. Metabolic rewiring and the
metastatic cascade are highly intertwined, co-operating to promote multiple steps of cancer …
metastatic cascade are highly intertwined, co-operating to promote multiple steps of cancer …
Obesity-induced inflammation and desmoplasia promote pancreatic cancer progression and resistance to chemotherapy
It remains unclear how obesity worsens treatment outcomes in patients with pancreatic
ductal adenocarcinoma (PDAC). In normal pancreas, obesity promotes inflammation and …
ductal adenocarcinoma (PDAC). In normal pancreas, obesity promotes inflammation and …
Cancer and inflammation
LL Munn - Wiley Interdisciplinary Reviews: Systems Biology …, 2017 - Wiley Online Library
The relationship between inflammation and cancer has been recognized since the 17th
century, 1 and we now know much about the cells, cytokines and physiological processes …
century, 1 and we now know much about the cells, cytokines and physiological processes …
Role of VEGFs/VEGFR-1 signaling and its inhibition in modulating tumor invasion: experimental evidence in different metastatic cancer models
C Ceci, MG Atzori, PM Lacal, G Graziani - International journal of …, 2020 - mdpi.com
The vascular endothelial growth factor (VEGF) family members, VEGF-A, placenta growth
factor (PlGF), and to a lesser extent VEGF-B, play an essential role in tumor-associated …
factor (PlGF), and to a lesser extent VEGF-B, play an essential role in tumor-associated …
[HTML][HTML] VEGFR1 signaling in retinal angiogenesis and microinflammation
Five vascular endothelial growth factor receptor (VEGFR) ligands (VEGF-A,-B,–C,-D, and
placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 …
placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 …
Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2
J Incio, JA Ligibel, DT McManus, P Suboj… - Science translational …, 2018 - science.org
Anti–vascular endothelial growth factor (VEGF) therapy has failed to improve survival in
patients with breast cancer (BC). Potential mechanisms of resistance to anti-VEGF therapy …
patients with breast cancer (BC). Potential mechanisms of resistance to anti-VEGF therapy …
Therapeutic implication of vascular endothelial growth factor receptor-1 (VEGFR-1) targeting in cancer cells and tumor microenvironment by competitive and non …
PM Lacal, G Graziani - Pharmacological research, 2018 - Elsevier
The vascular endothelial growth factor receptor-1 (VEGFR-1) is a tyrosine kinase receptor
for VEGF-A, VEGF-B, and placental growth factor (PlGF) ligands that is expressed in …
for VEGF-A, VEGF-B, and placental growth factor (PlGF) ligands that is expressed in …