Despite much progress in understanding the genetics of syndromic tooth agenesis (TA), the
causes of the most common, isolated TA remain elusive. Recent studies have identified …

Dental enamel is hardest tissue in the body and is produced by dental epithelial cells
residing in the tooth. Their cell fates are tightly controlled by transcriptional programs that are …

Sox2 marks dental epithelial stem cells (DESCs) in both mammals and reptiles, and in this
article we demonstrate several Sox2 transcriptional mechanisms that regulate dental stem …

Epithelial signaling centers control epithelial invagination and organ development, but how
these centers are specified remains unclear. We report that Pitx2 (the first transcriptional …

The mechanisms that regulate post-natal growth of the craniofacial complex and that
ultimately determine the size and shape of our faces are not well understood. Hippo …

T-box transcription factor TBX1 is the major candidate gene for 22q11. 2 deletion syndrome
(22q11. 2DS, DiGeorge syndrome/Velo-cardio-facial syndrome), whose phenotypes include …

Clefting of the lip, with or without palatal involvement (CLP), is associated with a higher
incidence of developmental tooth abnormalities, including hypodontia and supernumerary …

Basic-helix-loop-helix (bHLH) transcription factors play an important role in various organs'
development; however, a tooth-specific bHLH factor has not been reported. In this study, we …

Objectives To identify the molecular etiology of distinct dental anomalies found in eight Thai
patients and explore the mutational effects on cellular functions. Materials and Methods …

While many effectors have been identified in enamel matrix and cells via genetic studies,
physiological networks underlying their expression levels and thus the natural spectrum of …