Articular cartilage damage and osteoarthritis (OA) are common orthopedic diseases in both
humans and dogs. Once damaged, the articular cartilage seldom undergoes spontaneous …

Semaphorin 3A (Sema3A) is a neuroinformatic protein molecule with widespread
expression across various tissues and organs. Recent investigations have unveiled its …

Abstract Design and development of scaffold structures for osteochondral (OC) interface
regeneration is a significant engineering challenge. Recent efforts are aimed at …

While many injectable viscosupplementation products are available for osteoarthritis (OA)
management, multiple hydrogel functional attributes may be further optimized for efficacy …

Thermo-responsive hyaluronan-based hydrogels and FE002 human primary
chondroprogenitor cell sources have both been previously proposed as modern therapeutic …

Drug localisation is still one of the main challenges in treating pathologies affecting
cartilage; poly-beta-amino-esters (PBAEs) drug conjugates are a possible solution; …

Subchondral bone structure has been observed to change in osteoarthritis (OA). However, it
remains unclear how the early-stage OA changes affect the mechanics (stresses and …

Objective Investigating whether mechanosensitive lncRNA H19 can directly target miR-148a
to alleviate cartilage damage in post-traumatic osteoarthritis (PTOA). Methods Thirty-two …

Hydrogels are networks of polymer chains that are swollen in water. In recent years, several
routes have been devised to make hydrogels that are flexible and bendable. This work …

The purpose of this study was to investigate the feasibility of adipose‐derived stem cells
(ADSCs) as the seed cells of cartilage tissue engineering. ADSCs were isolated from …