Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …

To curb the high cost of drug development, there is an urgent need to develop more
predictive tissue models using human cells to determine drug efficacy and safety in advance …

Rationale: Human-induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CM) are
increasingly being used for modeling heart disease and are under development for …

Rationale: There are several methods to measure cardiomyocyte and muscle contraction,
but these require customized hardware, expensive apparatus, and advanced informatics or …

Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …

It is now well recognized that many lifesaving oncology drugs may adversely affect the heart
and cardiovascular system, including causing irreversible cardiac injury that can result in …

Background: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
have emerged as a promising experimental tool for translational heart research and drug …

Key points Induced pluripotent stem cell‐derived cardiomyocytes (iPSC‐CMs) capture
patient‐specific genotype–phenotype relationships, as well as cell‐to‐cell variability of …

The advent of human induced pluripotent stem cell (hiPSC) technology has revitalized the
efforts in the past decade to realize more fully the potential of human embryonic stem cells …

Human heart failure due to myocardial infarction is a major health concern. The paucity of
organs for transplantation limits curative approaches for the diseased and failing adult heart …