Dendritic cells (DCs) collect and process antigens for presentation to T cells, but there are
many variations on this basic theme. DCs differ in the regulatory signals they transmit …

B-cell development is known to occur in a complex bone-marrow microenvironment but its
functional organization remains unclear. It is thought that bone-marrow stromal cells create …

One mechanism contributing to immunologic unresponsiveness toward tumors may be
presentation of tumor antigens by tolerogenic host APCs. We show that mouse tumor …

Stimulation of Flt3 receptor tyrosine kinase through its cognate ligand expands early
hematopoietic progenitor and dendritic cells (DCs) in humans and mice. The exact …

The cellular and molecular events that drive the early development of innate lymphoid cells
(ILCs) remain poorly understood. We show that the transcription factor TCF-1 is required for …

Early T lineage progenitors (ETPs) in the thymus are thought to develop from common
lymphoid progenitors (CLPs) in the bone marrow (BM). We compared thymic ETPs to BM …

Dendritic cells (DCs) are a heterogenous population of bone-marrow-derived immune cells.
Although all DCs share a common ability to process and present antigen to naive T cells for …

Abstract Viable Lin− CD27+ c-kit Hi Sca-1 Hi GFP+ cells recovered from heterozygous
RAG1/GFP knockin mice progressed through previously defined stages of B, T, and NK cell …

Flt3 ligand (Flt3L) is a growth factor for hemopoietic progenitors and can promote the
expansion of both conventional dendritic cells (DCs) and plasmacytoid predendritic cells (p …

T cells developing in the thymus are derived from hematopoietic stem cells (HSCs) in the
bone marrow (BM). Understanding the developmental steps linking multipotent HSCs to …