The role of Ca 2+ as a key and pivotal second messenger in cells depends largely on a wide
number of heterogeneous so-called calcium binding proteins (CBP), which have the ability …

In striated muscle, the protein troponin complex turns contraction on and off in a calcium-
dependent manner. The calcium-sensing component of the complex is troponin C, which is …

Skeletal myogenesis, like hematopoiesis, occurs in successive developmental stages that
involve different cell populations and expression of different genes. We show here that the …

The persistence of large blocks of homologous synteny and a high frequency of breakpoint
reuse are distinctive features of mammalian chromosomes that are not well understood in …

Cardiac troponin serum concentration is the primary marker used for the diagnosis of acute
coronary syndrome. Moreover, the measurement of cardiac troponin concentration is …

Fish and marine invertebrates constitute an important part of the human diet worldwide, and
their muscles are the major edible parts. The muscles are a rich source of proteins, which in …

The S100s are a large group of Ca2+ sensors found exclusively in vertebrates.
Transcriptomic and genomic data from the major radiations of mammals were used to derive …

Abstract Ca 2+ binding proteins (CBP) are of key importance for calcium to play its role as a
pivotal second messenger. CBP bind Ca 2+ in specific domains, contributing to the …

Zebrafish (Danio rerio) are widely used as vertebrate model in developmental genetics and
functional genomics as well as in cardiac structure-function studies. The zebrafish heart has …

Cardiac troponin C (cTnC) is the regulatory protein that initiates cardiac contraction in
response to Ca 2+. TnC binding Ca 2+ initiates a cascade of protein–protein interactions …