Abstract N-acylethanolamines (NAEs), which include the endocannabinoid anandamide,
represent an important family of signaling lipids in the brain. The lack of chemical probes …

Migraine is a disabling neurovascular disorder characterized by severe pain with still limited
efficient treatments. Endocannabinoids, the endogenous painkillers, emerged, alternative to …

Neuropathic pain is a neurological disorder that strongly affects the quality of life of patients.
The molecular and cellular mechanisms at the basis of the neuropathic pain establishment …

Background: Nucleoside reverse transcriptase inhibitors (NRTIs) are the cornerstone of the
antiretroviral therapy for human immunodeficiency virus/acquired immune deficiency …

Interfering with endocannabinoid (eCB) metabolism to increase their levels is a proven anti-
nociception strategy. However, because the eCB and prostanoid systems are intertwined …

Anandamide (AEA) is an important modulator of nociception in the spinal dorsal horn, acting
presynaptically through Cannabinoid (CB 1) and Transient receptor potential vanilloid …

Increased activity and excitability (sensitisation) of a series of molecules including the
transient receptor potential ion channel, vanilloid subfamily, member 1 (TRPV1) in pain …

Transient receptor potential ion channel, vanilloid subfamily, type 1 (TRPV1) cation channel,
and cannabinoid receptor 1 (CB1) are essential in the modulation of nociceptive signaling in …

Tissue injuries, including burns, are major causes of death and morbidity worldwide. These
injuries result in the release of intracellular molecules and subsequent inflammatory …

Background and Purpose Endocannabinoids play an important role in modulating spinal
nociceptive signalling, crucial for the development of pain. The cannabinoid CB1 receptor …