Dravet syndrome: A systematic literature review of the illness burden

A Strzelczyk, L Lagae, JM Wilmshurst… - Epilepsia …, 2023 - Wiley Online Library
We performed a systematic literature review and narrative synthesis according to a pre‐
registered protocol (Prospero: CRD42022376561) to identify the evidence associated with …

[HTML][HTML] Genetic variations in GABA metabolism and epilepsy

Y Feng, ZH Wei, C Liu, GY Li, XZ Qiao, YJ Gan… - Seizure, 2022 - Elsevier
Epilepsy is a paroxysmal brain disorder that results from an imbalance between neuronal
excitation and inhibition. Gamma-aminobutyric acid (GABA) is the most important inhibitory …

[HTML][HTML] EpilepsyNet: Novel automated detection of epilepsy using transformer model with EEG signals from 121 patient population

OS Lih, V Jahmunah, EE Palmer, PD Barua… - Computers in Biology …, 2023 - Elsevier
Background Epilepsy is one of the most common neurological conditions globally, and the
fourth most common in the United States. Recurrent non-provoked seizures characterize it …

The burden of illness in Lennox–Gastaut syndrome: a systematic literature review

A Strzelczyk, SM Zuberi, P Striano, F Rosenow… - Orphanet Journal of …, 2023 - Springer
Abstract Background Lennox–Gastaut syndrome (LGS) is a severe developmental and
epileptic encephalopathy characterized by drug-resistant epilepsy with multiple seizure …

Management of epileptic disorders using nanotechnology-based strategies for nose-to-brain drug delivery

M Shringarpure, S Gharat, M Momin… - Expert Opinion on Drug …, 2021 - Taylor & Francis
Introduction Epilepsy, a major neurological disorder affects about 1% of the Indian
population. The discovery of noninvasive strategies for epilepsy presents a challenge for the …

Advances in the mTOR signaling pathway and its inhibitor rapamycin in epilepsy

W Zhao, C Xie, X Zhang, J Liu, J Liu… - Brain and Behavior, 2023 - Wiley Online Library
Introduction Epilepsy is one of the most common and serious brain syndromes and has
adverse consequences on a patient's neurobiological, cognitive, psychological, and social …

The contribution of HCN channelopathies in different epileptic syndromes, mechanisms, modulators, and potential treatment targets: a systematic review

M Kessi, J Peng, H Duan, H He, B Chen… - Frontiers in Molecular …, 2022 - frontiersin.org
Background Hyperpolarization-activated cyclic nucleotide-gated (HCN) current reduces
dendritic summation, suppresses dendritic calcium spikes, and enables inhibitory GABA …

The metabolic role of ketogenic diets in treating epilepsy

K Imdad, T Abualait, A Kanwal, ZT AlGhannam… - Nutrients, 2022 - mdpi.com
Epilepsy is a long-term neurological condition that results in recurrent seizures.
Approximately 30% of patients with epilepsy have drug-resistant epilepsy (DRE). The …

Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity …

A Danis, YB Kilinc, IE Torun, F Hanci, E Kilinc… - Life Sciences, 2023 - Elsevier
Aims To investigate the effects of different doses of esculetin on epileptiform activity,
behavioral seizures, memory impairment, and cortical and hippocampal NF-κB, as a …

Anticonvulsant effect of quercetin in pentylenetetrazole (PTZ)-induced seizures in male mice: The role of anti-neuroinflammatory and anti-oxidative stress

Z Tavakoli, HT Dehkordi, Z Lorigooini… - International …, 2023 - Elsevier
Background Epilepsy is one of the major neurological disorders. The inflammatory process
and oxidative stress are closely related to seizure progression. Quercetin is a flavonoid with …