Acromegaly is a chronic systemic disease with many complications and is associated with
increased mortality when not adequately treated. Substantial advances in acromegaly …

The discovery of the growth hormone (GH)-mediated somatic factors (somatomedins),
insulin-like growth factor (IGF)-I and-II, has elicited an enormous interest primarily among …

Introduction Acromegaly is a rare, insidious disease resulting from the overproduction of
growth hormone (GH) and insulin-like growth factor 1 (IGF-1), and is associated with a range …

Context: GH excess causes an increase in bone turnover, but the consequences in terms of
skeletal fragility have long been uncertain due to the heterogeneity of studies dealing with …

Neuroendocrinology of bone is a new area of research based on the evidence that pituitary
hormones may directly modulate bone remodeling and metabolism. Skeletal fragility …

Context: Cross-sectional studies showed an elevated prevalence of vertebral fractures in
acromegaly. However, no data are available on incident vertebral fractures in this clinical …

Context Osteopathy and morphometric vertebral fractures (VFs) are emerging complications
in acromegaly. However, the prediction of VFs in this clinical setting is still a matter of …

Background: In active acromegaly, pathologically elevated GH and IGF-1 levels are
associated with increased bone turnover and a high bone mass, the latter being sustained …

Growth hormone (GH) and insulin-like growth factor-I (IGF-I) exert physiological actions on
the skeleton throughout life, by stimulating longitudinal bone growth in children, the …

Acromegaly is a chronic, progressive disease caused by a growth hormone (GH)-producing
pituitary adenoma, resulting in elevated GH and insulin-like growth factor 1 concentrations …