Oxidative cyclizations are important transformations that occur widely during natural product
biosynthesis. The transformations from acyclic precursors to cyclized products can afford …

Flavin-dependent monooxygenases catalyze a wide variety of chemo-, regio-and
enantioselective oxygenation reactions. As such, they are involved in key biological …

Covering: up to the end of May 2012 Riboflavin-based coenzymes, tightly bound to enzymes
catalyzing substrate oxidations and reductions, enable an enormous range of chemical …

Background Secondary metabolite production, a hallmark of filamentous fungi, is an
expanding area of research for the Aspergilli. These compounds are potent chemicals …

Covering: 2005 to 2011 This review studies the impact of whole genome sequencing on
Aspergillus secondary metabolite research. There has been a proliferation of many new …

Cyclization of linear peptidyl precursors produced by nonribosomal peptide synthetases
(NRPSs) is an important step in the biosynthesis of bioactive cyclic peptides. Whereas …

Spirotryprostatins, an indole alkaloid class of nonribosomal peptides isolated from
Aspergillus fumigatus, are known for their antimitotic activity in tumor cells. Because …

Covering: this review covers the literature from 1992 to 2018 To date, approximately 80
naturally-occurring secondary metabolites which are structurally-related to fumiquinazolines …

Notoamides produced by Aspergillus spp. bearing the bicyclo [2.2. 2] diazaoctane core
structure with unusual structural diversity represent a compelling system to understand the …

Neosartoryadins A (1) and B (2), both with a unique 6/6/6/5 quinazoline ring system
connected directly to a 6/5/5 imidazoindolone ring, together with three biogenetically related …