Purpose β-Thalassemia is an inherited blood disorder characterized by reduced or no
production of adult hemoglobin. Systematic identification of the burden of β-thalassemia with …

Ferroptosis is one type of programmed cell death discovered in recent years, which is
characterized by iron-dependent lipid peroxidation and participating in iron, lipid and …

Blood transfusion plays a prominent role in the management of patients with sickle cell
disease (SCD), but causes significant iron overload. As transfusions are used to treat the …

Randomized comparison data on the efficacy and safety of deferasirox for myocardial iron
removal in transfusion dependent patients are lacking. CORDELIA was a prospective …

Background Excessive iron accumulation leads to iron toxicity in the brain; however the
underlying mechanism is unclear. We investigated the effects of iron overload induced by …

Background The clinical application of cardiovascular magnetic resonance (CMR) T 2 and T
2* mapping is currently limited as ranges for healthy and cardiac diseases are poorly …

Background Iron overload, resulting from blood transfusions in patients with chronic
anemias, has historically been controlled with regular deferoxamine, but its parenteral …

Among the difficulties of living with β-thalassemia, patients frequently require blood
transfusions and experience iron overload. As serum ferritin (SF) provides an indication of …

Efforts to optimize the management of patients with β-thalassemia major (TM) continue to
expand. Evidence from biomedical research evaluating safe and careful processing …

Ovarian cancer (OC) is estimated to kill~ 14,000 women in the United States in 2019.
Current chemotherapies to treat OC initially show therapeutic efficacy but frequently drug …