Developing an understanding of the mechanism of voltage-gated ion channels in molecular
terms requires knowledge of the structure of the active and resting conformations. Although …

X-ray scattering is uniquely suited to the study of disordered systems and thus has the
potential to provide insight into dynamic processes where diffraction methods fail. In …

Voltage-dependent potassium channels (Kv) are homotetramers composed of four voltage
sensors and one pore domain. Because of high-level structural flexibility, the first …

Directly observing enzyme catalysis in real time at the molecular level has been a long-
standing goal of structural enzymology. Time-resolved serial crystallography methods at …

Computational modeling can provide a wealth of insight into how energy flow in proteins
mediates protein function. Computational methods can also address fundamental questions …

The use of TLS (translation/libration/screw) models to describe anisotropic displacement of
atoms within a protein crystal structure has become increasingly common. These models …

Because of its appealing simplicity, the anisotropic network model (ANM) has been widely
accepted and applied to study many molecular motion problems: such as ribosome motions …

Central to crystallographic structure solution is obtaining accurate phases in order to build a
molecular model, ultimately followed by refinement of that model to optimize its fit to the …

Spontaneous nucleation of actin is very inefficient in cells. To overcome this barrier, cells
have evolved a set of actin filament nucleators to promote rapid nucleation and …

In this article, we report a method for coarse-grained normal mode analysis called the
minimalist network model. The main features of the method are that it can deliver accurate …