In aerobes, oxygen is essential for maintenance of life. However, incomplete reduction of
oxygen leads to generation of reactive oxygen species. These oxidants oxidise biological …

Cytochromes P450s (CYPs) constitute a superfamily of enzymes that catalyze the
metabolism of drugs and other substances. Endogenous substrates of CYPs include …

Quinones represent a class of toxicological intermediates, which can create a variety of
hazardous effects in vivo including, acute cytotoxicity, immunotoxicity, and carcinogenesis …

Many endocrine disrupting chemicals (EDCs) adversely impact estrogen signaling by
interacting with two estrogen receptors (ERs): ERα and ERβ. Though the receptors have …

Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

Several studies show that a significantly stronger association is obvious between increased
body mass index (BMI) and higher breast cancer incidence. Furthermore, obese women are …

Selective estrogen receptor modulators (SERMs) are a diverse group of nonsteroidal
compounds that function as agonists or antagonists for estrogen receptors (ERs) in a target …

Tamoxifen is a central component of the treatment of estrogen receptor (ER)-positive breast
cancer as a partial agonist of ER. It has been clinically used for the last 30 years and is …

In this review, we have focused mainly on the study of their antioxidant and pro-oxidant
capacity, and the analysis of the oxidation of the catechol group to o-quinone. The redox …

Mechanisms of Chemical Carcinogenicity and Mutagenicity: A Review with Implications for
Predictive Toxicology | Chemical Reviews ACS ACS Publications C&EN CAS Find my …