Assessments of population genetic structure have become an increasing focus as they can
provide valuable insight into patterns of migration and gene flow. structure, the most highly …

Genetic admixture of divergent intraspecific lineages is increasingly suspected to have an
important role in the success of colonising populations. However, admixture is not a …

Current methods for inferring population structure from genetic data do not provide formal
significance tests for population differentiation. We discuss an approach to studying …

Human Evolutionary Genetics is a groundbreaking text which for the first time brings
together molecular genetics and genomics to the study of the origins and movements of …

Identifying the ancestry of chromosomal segments of distinct ancestry has a wide range of
applications from disease mapping to learning about history. Most methods require the use …

A whole-genome admixture scan in 1,597 African Americans identified a 3.8 Mb interval on
chromosome 8q24 as significantly associated with susceptibility to prostate cancer …

Genome-wide association studies (GWASs) are the method most often used by geneticists
to interrogate the human genome, and they provide a cost-effective way to identify the …

Population stratification (PS) is a primary consideration in studies of genetic determinants of
human traits. Failure to control for PS may lead to confounding, causing a study to fail for …

Pharmacogenetics is being used to develop personalized therapies specific to subjects from
different ethnic or racial groups. To date, pharmacogenetic studies have been primarily …

Admixed populations present unique opportunities to discover the genetic factors underlying
many multifactorial diseases. The geographical position and complex history of South Africa …