Alcohol use disorders

AF Carvalho, M Heilig, A Perez, C Probst, J Rehm - The Lancet, 2019 - thelancet.com
Alcohol use disorders consist of disorders characterised by compulsive heavy alcohol use
and loss of control over alcohol intake. Alcohol use disorders are some of the most prevalent …

Alcohol dehydrogenases, aldehyde dehydrogenases, and alcohol use disorders: a critical review

HJ Edenberg, JN McClintick - Alcoholism: Clinical and …, 2018 - Wiley Online Library
Alcohol use disorders (AUDs) are complex traits, meaning that variations in many genes
contribute to the risk, as does the environment. Although the total genetic contribution to risk …

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

M Liu, Y Jiang, R Wedow, Y Li, DM Brazel, F Chen… - Nature …, 2019 - nature.com
Tobacco and alcohol use are leading causes of mortality that influence risk for many
complex diseases and disorders. They are heritable, and etiologically related, behaviors that …

Smoking, alcohol consumption, and 24 gastrointestinal diseases: Mendelian randomization analysis

S Yuan, J Chen, X Ruan, Y Sun, K Zhang, X Wang, X Li… - Elife, 2023 - elifesciences.org
Background: Whether the positive associations of smoking and alcohol consumption with
gastrointestinal diseases are causal is uncertain. We conducted this Mendelian …

Genome-wide association study meta-analysis of the alcohol use disorders identification test (AUDIT) in two population-based cohorts

S Sanchez-Roige, AA Palmer… - American Journal of …, 2019 - Am Psychiatric Assoc
Objective: Alcohol use disorders are common conditions that have enormous social and
economic consequences. Genome-wide association analyses were performed to identify …

Modifiable pathways in Alzheimer's disease: Mendelian randomisation analysis

SC Larsson, M Traylor, R Malik, M Dichgans… - bmj, 2017 - bmj.com
Objective To determine which potentially modifiable risk factors, including socioeconomic,
lifestyle/dietary, cardiometabolic, and inflammatory factors, are associated with Alzheimer's …

[HTML][HTML] Alcohol-induced oxidative stress and the role of antioxidants in alcohol use disorder: a systematic review

EE Tsermpini, A Plemenitaš Ilješ, V Dolžan - Antioxidants, 2022 - mdpi.com
Alcohol use disorder (AUD) is a highly prevalent, comorbid, and disabling disorder. The
underlying mechanism of ethanol neurotoxicity and the involvement of oxidative stress is still …

Genetics of substance use disorders: a review

JD Deak, EC Johnson - Psychological medicine, 2021 - cambridge.org
Substance use disorders (SUDs) are prevalent and result in an array of negative
consequences. They are influenced by genetic factors (h2=~ 50%). Recent years have …

A genome-wide association study of bitter and sweet beverage consumption

VW Zhong, A Kuang, RD Danning, P Kraft… - Human molecular …, 2019 - academic.oup.com
Except for drinking water, most beverages taste bitter or sweet. Taste perception and
preferences are heritable and determinants of beverage choice and consumption …

[HTML][HTML] Alcohol consumption and cardiovascular disease risk: placing new data in context

AG Hoek, S van Oort, KJ Mukamal… - Current atherosclerosis …, 2022 - Springer
Purpose of Review A clear link between excessive alcohol consumption and cardiovascular
disease (CVD) has been established, but no consensus exists on the effects of moderate …