Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases
Abstract Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with
over 100 known substrates to deal with. How does GSK3 maintain control to selectively …
over 100 known substrates to deal with. How does GSK3 maintain control to selectively …
Circadian Rhythms and Sleep in Drosophila melanogaster
C Dubowy, A Sehgal - Genetics, 2017 - academic.oup.com
The advantages of the model organism Drosophila melanogaster, including low genetic
redundancy, functional simplicity, and the ability to conduct large-scale genetic screens …
redundancy, functional simplicity, and the ability to conduct large-scale genetic screens …
Molecular genetic analysis of circadian timekeeping in Drosophila
PE Hardin - Advances in genetics, 2011 - Elsevier
A genetic screen for mutants that alter circadian rhythms in Drosophila identified the first
clock gene—the period (per) gene. The per gene is a central player within a transcriptional …
clock gene—the period (per) gene. The per gene is a central player within a transcriptional …
CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch
R Narasimamurthy, SR Hunt, Y Lu… - Proceedings of the …, 2018 - National Acad Sciences
Multisite phosphorylation of the PERIOD 2 (PER2) protein is the key step that determines the
period of the mammalian circadian clock. Previous studies concluded that an unidentified …
period of the mammalian circadian clock. Previous studies concluded that an unidentified …
Design, synthesis, antineoplastic activity of new pyrazolo [3, 4-d] pyrimidine derivatives as dual CDK2/GSK3β kinase inhibitors; molecular docking study, and ADME …
In the current study, novel pyrazolo [3, 4-d] pyrimidine derivatives 5a–h were designed and
synthesized as targeted anti-cancer agents through dual CDK2/GSK-3β inhibition. The …
synthesized as targeted anti-cancer agents through dual CDK2/GSK-3β inhibition. The …
Circadian timekeeping and output mechanisms in animals
PE Hardin, S Panda - Current opinion in neurobiology, 2013 - Elsevier
Highlights•Work on circadian period determination and output gene regulation are
reviewed.•Clock protein glycosylation, ubiquitylation and translation influence 24 hours …
reviewed.•Clock protein glycosylation, ubiquitylation and translation influence 24 hours …
Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3β inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies
The serine/threonine protein kinases CDK2 and GSK-3β are key oncotargets in breast
cancer cell lines, therefore, in the present study three series of oxindole-benzofuran hybrids …
cancer cell lines, therefore, in the present study three series of oxindole-benzofuran hybrids …
Circadian rhythms and mood regulation: insights from pre-clinical models
CA McClung - European neuropsychopharmacology, 2011 - Elsevier
Affective disorders such as major depression, bipolar disorder, and seasonal affective
disorder are associated with major disruptions in circadian rhythms. Indeed, altered …
disorder are associated with major disruptions in circadian rhythms. Indeed, altered …
[HTML][HTML] NEMO/NLK phosphorylates PERIOD to initiate a time-delay phosphorylation circuit that sets circadian clock speed
The speed of circadian clocks in animals is tightly linked to complex phosphorylation
programs that drive daily cycles in the levels of PERIOD (PER) proteins. Using Drosophila …
programs that drive daily cycles in the levels of PERIOD (PER) proteins. Using Drosophila …
Links between circadian rhythms and psychiatric disease
IN Karatsoreos - Frontiers in behavioral neuroscience, 2014 - frontiersin.org
Determining the cause of psychiatric disorders is a goal of modern neuroscience, and will
hopefully lead to the discovery of treatments to either prevent or alleviate the suffering …
hopefully lead to the discovery of treatments to either prevent or alleviate the suffering …