Cellular senescence represents a distinct cell fate characterized by replicative arrest in
response to a host of extrinsic and intrinsic stresses. Senescence facilitates programming …

Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

Aging of the brain can manifest itself as a memory and cognitive decline, which has been
shown to frequently coincide with changes in the structural plasticity of dendritic spines …

Cellular senescence is a homeostatic biological process characterized by a permanent state
of cell cycle arrest that can contribute to the decline of the regenerative potential and …

With recent rapid progress in research on aging, there is increasing evidence that many
features commonly considered to be mechanisms or drivers of aging in fact represent …

Senescence is a complex cellular stress response that abolishes proliferative capacity and
generates a unique secretory pattern that is implicated in organismal aging and age-related …

Nuclear chromosomes transcribe far more RNA than required to encode protein. Here we
investigate whether non-coding RNA broadly contributes to cytological-scale chromosome …

Cellular senescence is a stable form of cell cycle arrest in response to various stressors.
While it serves as an endogenous pro-resolving mechanism, detrimental effects ensue when …

Mammalian aging is characterized by the progressive loss of tissue function and increased
risk for disease. Accumulation of senescent cells in aging tissues partly contributes to this …

Accumulation of senescent cells has a causative role in the pathology of age-related
disorders including atherosclerosis (AS) and cardiovascular diseases (CVDs). However, the …