CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of
substrates, controls several signaling pathways, and is implicated in a plethora of human …

A targeted delivery system based on the polymeric nanoparticles as a drug carrier
represents a marvelous avenue for cancer therapy. The pivotal characteristics of this system …

The casein kinase 2 (CK2) protein kinase is a pro-survival kinase and therapeutic target in
treatment of various human cancers. CK2 overexpression has been demonstrated in …

Platelets have a crucial role in haemostasis and atherothrombosis. Pharmacological control
of platelet hyper-reactivity has become a cornerstone in the prevention of thrombo …

The association of protein kinase CK2 (formerly casein kinase II or 2) with cell growth and
proliferation in cells was apparent at early stages of its investigation. A cancer-specific role …

Transcription of the ribosomal RNA genes by the dedicated RNA polymerase I enzyme and
subsequent processing of the ribosomal RNA are fundamental control steps in the synthesis …

By deconvoluting 238,073 bioactive molecules in the ChEMBL library into extended Murcko
ring systems, we identified a set of 2245 ring systems present in at least 10 molecules …

Abstract Chronic Lymphocytic Leukemia (CLL) is a lymphoproliferative disorder with either
indolent or aggressive clinical course. Current treatment regiments have significantly …

CK2 is a ubiquitously expressed, constitutively active Ser/Thr protein kinase, which is
considered the most pleiotropic protein kinase in the human kinome. Such a pleiotropy …

Excessive erythrocytosis (EE) is a major hallmark of patients suffering from chronic mountain
sickness (CMS, also known as Monge's disease) and is responsible for major morbidity and …