[HTML][HTML] Current status of latency reversing agents facing the heterogeneity of HIV-1 cellular and tissue reservoirs
One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …
In Vivo T Cell-Targeting Nanoparticle Drug Delivery Systems: Considerations for Rational Design
T cells play an important role in immunity and repair and are implicated in diseases,
including blood cancers, viral infections, and inflammation, making them attractive targets for …
including blood cancers, viral infections, and inflammation, making them attractive targets for …
[HTML][HTML] Identification of genetically intact HIV-1 proviruses in specific CD4+ T cells from effectively treated participants
Latent replication-competent HIV-1 persists in individuals on long-term antiretroviral therapy
(ART). We developed the Full-Length Individual Proviral Sequencing (FLIPS) assay to …
(ART). We developed the Full-Length Individual Proviral Sequencing (FLIPS) assay to …
[HTML][HTML] Defective HIV-1 proviruses are expressed and can be recognized by cytotoxic T lymphocytes, which shape the proviral landscape
Despite antiretroviral therapy, HIV-1 persists in memory CD4+ T cells, creating a barrier to
cure. The majority of HIV-1 proviruses are defective and considered clinically irrelevant …
cure. The majority of HIV-1 proviruses are defective and considered clinically irrelevant …
[HTML][HTML] HIV persists throughout deep tissues with repopulation from multiple anatomical sources
BACKGROUND Understanding HIV dynamics across the human body is important for cure
efforts. This goal has been hampered by technical difficulties and the challenge of obtaining …
efforts. This goal has been hampered by technical difficulties and the challenge of obtaining …
[图书][B] Data integration, manipulation and visualization of phylogenetic trees
G Yu - 2022 - taylorfrancis.com
Data Integration, Manipulation and Visualization of Phylogenetic Trees introduces and
demonstrates data integration, manipulation and visualization of phylogenetic trees using a …
demonstrates data integration, manipulation and visualization of phylogenetic trees using a …
[HTML][HTML] HIV rebound is predominantly fueled by genetically identical viral expansions from diverse reservoirs
Viral rebound upon stopping combined antiretroviral therapy poses a major barrier toward
an HIV cure. Cellular and anatomical sources responsible for reinitiating viral replication …
an HIV cure. Cellular and anatomical sources responsible for reinitiating viral replication …
[HTML][HTML] HIV infects astrocytes in vivo and egresses from the brain to the periphery
V Lutgen, SD Narasipura, HJ Barbian… - PLoS …, 2020 - journals.plos.org
HIV invades the brain during acute infection. Yet, it is unknown whether long-lived infected
brain cells release productive virus that can egress from the brain to re-seed peripheral …
brain cells release productive virus that can egress from the brain to re-seed peripheral …
[HTML][HTML] Interval dosing with the HDAC inhibitor vorinostat effectively reverses HIV latency
NM Archin, JL Kirchherr, JAM Sung… - The Journal of …, 2017 - Am Soc Clin Investig
BACKGROUND. The histone deacetylase (HDAC) inhibitor vorinostat (VOR) can increase
HIV RNA expression in vivo within resting CD4+ T cells of aviremic HIV+ individuals …
HIV RNA expression in vivo within resting CD4+ T cells of aviremic HIV+ individuals …
Paired quantitative and qualitative assessment of the replication-competent HIV-1 reservoir and comparison with integrated proviral DNA
JCC Lorenzi, YZ Cohen, LB Cohn… - Proceedings of the …, 2016 - National Acad Sciences
HIV-1–infected individuals harbor a latent reservoir of infected CD4+ T cells that is not
eradicated by antiretroviral therapy (ART). This reservoir presents the greatest barrier to an …
eradicated by antiretroviral therapy (ART). This reservoir presents the greatest barrier to an …