Cardiovascular complications due to accelerated arterial stiffening and atherosclerosis are
the leading cause of morbimortality in Western society. Both pathologies are frequently …

In mammals, phosphate balance is maintained by influx and efflux via the intestines,
kidneys, bone, and soft tissue, which involves multiple sodium/phosphate (Na+/Pi) …

Vascular calcification is associated with cardiovascular morbidity and mortality.
Hyperphosphatemia is an important contributor to vascular calcification. Our previous …

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Hypertrophic chondrocytes are the master regulators of endochondral ossification; however,
their ultimate cell fates cells remain largely elusive due to their transient nature. Historically …

The spatial and temporal coordination of the many events required for osteogenic cells to
create a mineralized matrix are only partially understood. The complexity of this process …

Rickets is seen in association with vitamin D deficiency and in several genetic disorders
associated with abnormal mineral ion homeostasis. Studies in vitamin D receptor (VDR)-null …

Phosphate is an essential component of life and must be actively transported into cells
against its electrochemical gradient. In vertebrates, two unrelated families of Na+-dependent …

Chronic kidney disease with hyperphosphatemia is associated with accelerated
atherosclerosis and endothelial dysfunction. However, the contribution of high serum …

Although considerable advances in our understanding of the mechanisms of phosphate
homeostasis and skeleton mineralization have recently been made, little is known about the …