The multiplex model of the genetics of Alzheimer's disease
Genes play a strong role in Alzheimer's disease (AD), with late-onset AD showing heritability
of 58–79% and early-onset AD showing over 90%. Genetic association provides a robust …
of 58–79% and early-onset AD showing over 90%. Genetic association provides a robust …
ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries
This review summarizes the last decade of work by the ENIGMA (E nhancing N euro I
maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 …
maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 …
Genetic variants associated with longitudinal changes in brain structure across the lifespan
Human brain structure changes throughout the lifespan. Altered brain growth or rates of
decline are implicated in a vast range of psychiatric, developmental and neurodegenerative …
decline are implicated in a vast range of psychiatric, developmental and neurodegenerative …
Shared mechanisms across the major psychiatric and neurodegenerative diseases
Several common psychiatric and neurodegenerative diseases share epidemiologic risk;
however, whether they share pathophysiology is unclear and is the focus of our …
however, whether they share pathophysiology is unclear and is the focus of our …
Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images
Cardiovascular health interacts with cognitive and mental health in complex ways, yet little is
known about the phenotypic and genetic links of heart-brain systems. We quantified heart …
known about the phenotypic and genetic links of heart-brain systems. We quantified heart …
Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive …
Volumetric variations of the human brain are heritable and are associated with many brain-
related complex traits. Here we performed genome-wide association studies (GWAS) of 101 …
related complex traits. Here we performed genome-wide association studies (GWAS) of 101 …
Discovery of 42 genome-wide significant loci associated with dyslexia
C Doust, P Fontanillas, E Eising, SD Gordon, Z Wang… - Nature …, 2022 - nature.com
Reading and writing are crucial life skills but roughly one in ten children are affected by
dyslexia, which can persist into adulthood. Family studies of dyslexia suggest heritability up …
dyslexia, which can persist into adulthood. Family studies of dyslexia suggest heritability up …
Understanding the genetic determinants of the brain with MOSTest
Regional brain morphology has a complex genetic architecture, consisting of many common
polymorphisms with small individual effects. This has proven challenging for genome-wide …
polymorphisms with small individual effects. This has proven challenging for genome-wide …
Replicable brain–phenotype associations require large-scale neuroimaging data
Numerous neuroimaging studies have investigated the neural basis of interindividual
differences but the replicability of brain–phenotype associations remains largely unknown …
differences but the replicability of brain–phenotype associations remains largely unknown …
Cell subtype-specific effects of genetic variation in the Alzheimer's disease brain
The relationship between genetic variation and gene expression in brain cell types and
subtypes remains understudied. Here, we generated single-nucleus RNA sequencing data …
subtypes remains understudied. Here, we generated single-nucleus RNA sequencing data …