Myocardial ischemia has a high incidence and mortality rate, and reperfusion is currently the
standard intervention. However, reperfusion may lead to further myocardial damage, known …

On the one hand, reactive oxygen species (ROS) are involved in the onset and progression
of a wide array of diseases. On the other hand, these are a part of signaling pathways …

Background: Loss of brain-derived neurotrophic factor (BDNF)/TrkB (tropomyosin kinase
receptor B) signaling accounts for brain and cardiac disorders. In neurons, β-adrenergic …

MicroRNAs play a crucial role in regulating the immune responses induced by
ischemia/reperfusion injury. Through their ability to modulate gene expression, microRNAs …

Preconditioning, postconditioning, and remote conditioning of the myocardium enhance the
ability of the heart to withstand a prolonged ischemia/reperfusion insult and the potential to …

Glutathione (GSH) depletion, and impaired redox homeostasis have been observed in
experimental animal models and patients with epilepsy. Pleiotropic strategies that elevate …

MTORC1 integrates signaling from the immune microenvironment to regulate T cell
activation, differentiation, and function. TSC2 in the tuberous sclerosis complex tightly …

Rationale The nutrient sensing mechanistic target of rapamycin complex 1 (mTORC1) and
its primary inhibitor, tuberin (TSC2), are cues for the development of cardiac hypertrophy …

Myocardial ischemia/reperfusion (MI/R) injury is a major cause of adverse outcomes of
revascularization following myocardial infarction. Anaerobic glycolysis during myocardial …

Myocardial ischemia is the most common cardiovascular disease. Reperfusion, an important
myocardial ischemia tool, causes unexpected and irreversible damage to cardiomyocytes …