Head and neck cancer, including oral squamous cell carcinoma (OSCC), is the sixth leading
malignancy worldwide. OSCC is an aggressive tumor and its prognosis has exhibited little …

Recent studies describing the mutational landscape of head and neck squamous cell
carcinoma (HNSCC) on a genomic scale by our group and others, including The Cancer …

Background TP53 mutation is the most common mutation in hepatocellular carcinoma
(HCC), and it affects the progression and prognosis of HCC. We investigated how TP53 …

Mutant TP53 is an adverse risk factor in acute myeloid leukemia (AML), but large-scale
integrated genomic-proteomic analyses of TP53 alterations in patients with AML remain …

Estimating the effects of variants found in disease driver genes opens the door to
personalized therapeutic opportunities. Clinical associations and laboratory experiments …

Purpose: Head and neck squamous cell carcinoma (HNSCC) is a frequently devastating
cancer that affects more than a half million people annually worldwide. Although some …

Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer worldwide
and in the United States. OSCC remains a major cause of morbidity and mortality in patients …

The human TP53 locus, located on the short arm of chromosome 17, encodes a tumour
suppressor protein which functions as a tetrameric transcription factor capable of regulating …

Background To determine genomic alterations in head and neck squamous cell carcinoma
(HNSCC) using formalin-fixed, paraffin-embedded (FFPE) tumors obtained through routine …

TP53 gene alteration confers inferior prognosis in refractory/relapse aggressive B-cell non-
Hodgkin lymphoma (r/r B-NHL). From September 2016 to September 2020, 257 r/r B-NHL …