Brain circuits for pain and its treatment
Pain is a multidimensional experience with sensory-discriminative, affective-motivational,
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …
[HTML][HTML] Multimodal general anesthesia: theory and practice
EN Brown, KJ Pavone, M Naranjo - Anesthesia & analgesia, 2018 - journals.lww.com
Balanced general anesthesia, the most common management strategy used in anesthesia
care, entails the administration of different drugs together to create the anesthetic state …
care, entails the administration of different drugs together to create the anesthetic state …
Neurobiological interactions between stress and the endocannabinoid system
Stress affects a constellation of physiological systems in the body and evokes a rapid shift in
many neurobehavioral processes. A growing body of work indicates that the …
many neurobehavioral processes. A growing body of work indicates that the …
[HTML][HTML] Elucidating an affective pain circuit that creates a threat memory
Animals learn to avoid harmful situations by associating a neutral stimulus with a painful
one, resulting in a stable threat memory. In mammals, this form of learning requires the …
one, resulting in a stable threat memory. In mammals, this form of learning requires the …
The basolateral amygdala-anterior cingulate pathway contributes to depression-like behaviors and comorbidity with chronic pain behaviors in male mice
LJ Becker, C Fillinger, R Waegaert, SH Journée… - Nature …, 2023 - nature.com
While depression and chronic pain are frequently comorbid, underlying neuronal circuits
and their psychopathological relevance remain poorly defined. Here we show in mice that …
and their psychopathological relevance remain poorly defined. Here we show in mice that …
The mesolimbic dopamine system in chronic pain and associated affective comorbidities
RA Serafini, KD Pryce, V Zachariou - Biological psychiatry, 2020 - Elsevier
Chronic pain is a complex neuropsychiatric disorder characterized by sensory, cognitive,
and affective symptoms. Over the past 2 decades, researchers have made significant …
and affective symptoms. Over the past 2 decades, researchers have made significant …
Dual and opposing functions of the central amygdala in the modulation of pain
TD Wilson, S Valdivia, A Khan, HS Ahn, AP Adke… - Cell reports, 2019 - cell.com
Pain perception is essential for survival and can be amplified or suppressed by
expectations, experiences, and context. The neural mechanisms underlying bidirectional …
expectations, experiences, and context. The neural mechanisms underlying bidirectional …
Common brain mechanisms of chronic pain and addiction
I Elman, D Borsook - Neuron, 2016 - cell.com
While chronic pain is considered by some to be a CNS disease, little is understood about
underlying neurobiological mechanisms. Addiction models have heuristic value in this …
underlying neurobiological mechanisms. Addiction models have heuristic value in this …
Left and right hemispheric lateralization of the amygdala in pain
Hemispheric asymmetries within the brain have been identified across taxa and have been
extensively studied since the early 19th century. Here, we discuss lateralization of a brain …
extensively studied since the early 19th century. Here, we discuss lateralization of a brain …
[图书][B] The ancient origins of consciousness: How the brain created experience
TE Feinberg, J Mallatt - 2016 - books.google.com
How consciousness appeared much earlier in evolutionary history than is commonly
assumed, and why all vertebrates and perhaps even some invertebrates are conscious …
assumed, and why all vertebrates and perhaps even some invertebrates are conscious …