Galanin was first identified 30 years ago as a" classic neuropeptide," with actions primarily
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …

Regenerative failure remains a significant barrier for functional recovery after central
nervous system (CNS) injury. As such, understanding the physiological processes that …

Background The sites of action and cellular mechanisms by which spinal cord stimulation
reduces neuropathic pain remain unclear. Methods We examined the effect of bipolar …

Axon injury in the peripheral nervous system (PNS) induces a regeneration-associated gene
(RAG) response. Atf3 (activating transcription factor 3) is such a RAG and ATF3's …

We only have a rudimentary understanding of the molecular and cellular determinants of
nerve regeneration and neuropathic pain in humans. This cohort study uses the most …

Following axotomy, the activation of multiple intracellular signaling cascades causes the
expression of a cocktail of regeneration-associated transcription factors which interact with …

Human dental follicle cells (DFCs) derived from wisdom teeth are precursor cells for
cementoblasts. In this study, we recognized that naïve DFCs express constitutively the early …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of complex
etiology leading to motor neuron degeneration. Many gene alterations cause this pathology …

Peripheral nerve injury models are used to investigate processes that can potentially be
exploited in CNS injury. A consistent change that occurs in injured peripheral neurons is an …

The intracellular signaling pathways mediating the neurotrophic actions of pituitary
adenylate cyclase‐activating polypeptide (PACAP) were investigated in human …