The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

K Dheda, T Gumbo, G Maartens, KE Dooley… - The lancet Respiratory …, 2017 - thelancet.com
Global tuberculosis incidence has declined marginally over the past decade, and
tuberculosis remains out of control in several parts of the world including Africa and Asia …

Prevalence of long-term physical sequelae among patients treated with multi-drug and extensively drug-resistant tuberculosis: a systematic review and meta-analysis

TY Akalu, ACA Clements, HF Wolde, KA Alene - EClinicalMedicine, 2023 - thelancet.com
Background Physical sequelae related to multi-drug resistant tuberculosis (MDR-TB) and
extensively drug-resistant tuberculosis (XDR-TB) are emerging and under-recognised …

Bedaquiline in the treatment of multidrug-and extensively drug-resistant tuberculosis

AS Pym, AH Diacon, SJ Tang… - European …, 2016 - Eur Respiratory Soc
Bedaquiline, a diarylquinoline, improved cure rates when added to a multidrug-resistant
tuberculosis (MDR-TB) treatment regimen in a previous placebo-controlled, phase 2 trial …

Management of difficult multidrug‐resistant tuberculosis and extensively drug‐resistant tuberculosis: update 2012

KC CHANG, WWAI YEW - Respirology, 2013 - Wiley Online Library
ABSTRACT Multidrug‐resistant (MDR) tuberculosis (TB) denotes bacillary resistance to at
least isoniazid and rifampicin. Extensively drug‐resistant (XDR) TB is MDR‐TB with …

Safety implications of combined antiretroviral and anti-tuberculosis drugs

M Cerrone, M Bracchi, S Wasserman… - Expert opinion on …, 2020 - Taylor & Francis
Introduction: Antiretroviral and anti-tuberculosis (TB) drugs are often co-administered in
people living with HIV (PLWH). Early initiation of antiretroviral therapy (ART) during TB …

Gender differences among patients with drug resistant tuberculosis and HIV co-infection in Uganda: a countrywide retrospective cohort study

JB Baluku, D Mukasa, F Bongomin… - BMC infectious …, 2021 - Springer
Background Gender differences among patients with drug resistant tuberculosis (DRTB) and
HIV co-infection could affect treatment outcomes. We compared characteristics and …

Nine-month, all-oral regimens for rifampin-resistant tuberculosis

L Guglielmetti, U Khan, GE Velasquez, M Gouillou… - MedRxiv, 2024 - medrxiv.org
Background After a history of poor treatments for rifampin-resistant tuberculosis (RR-TB),
recent advances have resulted in shorter, more effective treatments. However, they are not …

Pyrazinamide may improve fluoroquinolone-based treatment of multidrug-resistant tuberculosis

KC Chang, CC Leung, WW Yew… - Antimicrobial agents …, 2012 - Am Soc Microbiol
The role of pyrazinamide in the current treatment of multidrug-resistant (MDR) tuberculosis
(TB) is uncertain. From a territory-wide registry of MDR-TB cases diagnosed between 1995 …

[HTML][HTML] Quality of drug-resistant tuberculosis care: Gaps and solutions

Z Udwadia, J Furin - Journal of clinical tuberculosis and other …, 2019 - Elsevier
Drug-resistant forms of tuberculosis (DR-TB) are a significant cause of global morbidity and
mortality and the treatment of DR-TB is characterized by long and toxic regimens that result …

N‐Acetyl Cysteine as an Adjunct in the Treatment of Tuberculosis

DA Ejigu, SM Abay - Tuberculosis research and treatment, 2020 - Wiley Online Library
Oxidative stress is a common feature of tuberculosis (TB), and persons with reduced
antioxidants are at more risk of TB. TB patients with relatively severe oxidative stress had …