The increase in life expectancy has boosted the incidence of age-related pathologies
beyond social and economic sustainability. Consequently, there is an urgent need for …

Cellular senescence is an irreversible state of cell cycle arrest occurring in response to
stressful stimuli, such as telomere attrition, DNA damage, reactive oxygen species, and …

Myricetin is a critical nutritive component of diet providing immunological protection and
beneficial for maintaining good health. It is found in fruits, vegetables, tea, and wine. The …

The aging of mammals is accompanied by the progressive atrophy of tissues and organs
and the accumulation of random damage to macromolecular DNA, protein, and lipids …

A large number of diverse mechanisms that lead to cytoprotection have been described to
date. Perhaps, not surprisingly, the role of mitochondria in these phenomena is notable. In …

Background Although myricetin exerts anti-inflammation, anti-cancer, and anti-oxidation
effects, the relationship between myricetin and tumor necrosis factor alpha (TNF-α) …

Cellular energy demands are readily changed during physical exercise resulting in adaptive
responses by signaling proteins of metabolic processes, including the NAD+ dependent …

The tight coordination between mitochondrial biogenesis and mitophagy can be
dysregulated during aging, critically influencing whole-body metabolism, health, and …

Ageing is an inevitable fundamental process for people and is their greatest risk factor for
neurodegenerative disease. The ageing processes bring changes in cells that can drive the …

Background Muscle atrophy and weakness are adverse effects of high dose or the sustained
usage of glucocorticoids. Loss of mitochondria and degradation of protein are highly …