Chemotherapy is the main strategy for the treatment of cancer. However, the main problem
limiting the success of chemotherapy is the development of multidrug resistance. The …

Biologically active sphingolipids have key roles in the regulation of several fundamental
biological processes that are integral to cancer pathogenesis. Recent significant progress in …

Cannabinoids—the active components of Cannabis sativa and their derivatives—exert
palliative effects in cancer patients by preventing nausea, vomiting and pain and by …

" Sphingosin" was first described by JLW Thudichum in 1884 and structurally characterized
as 2S, 3R, 4E-2-aminooctadec-4-ene-1, 3-diol in 1947 by Herb Carter, who also proposed …

Sphingolipids have emerged as bioeffector molecules, controlling various aspects of cell
growth and proliferation in cancer, which is becoming the deadliest disease in the world …

The development of new therapeutic strategies is essential for the management of gliomas,
one of the most malignant forms of cancer. We have shown previously that the growth of the …

Ceramide, generated by the action of acid sphingomyelinase (ASM), has emerged as a
biochemical mediator of stimuli as diverse as ionizing radiation, chemotherapy, UVA light …

While ceramide has been proposed as a messenger for events as diverse as differentiation,
senescence, proliferation, and cell cycle arrest, a larger body of research has focused on its …

Retinoids are derivatives of vitamin A that include all trans-retinoic acid (ATRA), 13-cis-
retinoic acid,(13-cis-RA), and fenretinide (4-HPR). High levels of either ATRA or 13-cis-RA …

Sphingolipid metabolites have emerged as critical players in a number of fundamental
biological processes. Among them, sphingosine-1-phosphate (S1P) promotes cell survival …