During the generation of a successful adaptive immune response, multiple molecular
signals are required. A primary signal is the binding of cognate antigen to an antigen …

Germinal centers (GCs) are important sites of antibody affinity maturation. In the classical
model, the GC dark zone contains large centroblasts that are rapidly proliferating and …

Infants and the elderly share a high vulnerability to infections and therefore have specific
immunization requirements. Inducing potent and sustained B-cell responses is as …

Over the past several decades, B cell antigen receptor (BCR)-induced signaling pathways
have been described in extraordinary molecular detail, mainly from studies of B cell …

Humoral immunity depends on both rapid and long-term antibody production against
invading pathogens. This is achieved by the generation of spatially distinct extrafollicular …

Infants are capable of mounting adaptive immune responses, but their ability to develop long-
lasting immunity is limited. Understanding the particularities of the neonatal adaptive …

In response to infection or effective vaccination, naive antigen‐specific CD8+ T cells
undergo a dramatic highly orchestrated activation process. Initial encounter with an …

Although immune memory often lasts for life, this is not the case for certain vaccines in some
individuals. We sought a mechanism for this phenomenon by studying B cell responses to …

Despite the availability of advances in molecular diagnostic testing for infectious disease,
there is still a need for tools that advance clinical care and public health. Current methods …

Gammaherpesviruses chronically infect their host and are tightly associated with the
development of lymphoproliferative diseases and lymphomas, as well as several other types …