The proportion of approved chiral drugs and drug candidates under medical studies has
surged dramatically over the past two decades. As a consequence, the efficient synthesis of …

Automation has become an increasingly popular tool for synthetic chemists over the past
decade. Recent advances in robotics and computer science have led to the emergence of …

Autonomous process optimization involves the human intervention-free exploration of a
range process parameters to improve responses such as product yield and selectivity …

This is an overview of successes in the realm of catalytic homogeneous asymmetric
hydrogenation of substrates primarily of interest in the synthesis of pharmaceuticals in order …

The asymmetric hydrogenation of tetrasubstituted olefins provides direct access to very
useful biological molecules and intermediates. The development of the technology has been …

We report the development of a method to diastereoselectively access tetrasubstituted
alkenes via nickel-catalyzed Suzuki–Miyaura cross-couplings of enol tosylates and boronic …

Catalytic reductive coupling of enone, acrylate, or vinyl heteroaromatic pronucleophiles with
carbonyl or imine partners offers an alternative to base-mediated enolization in aldol-and …

Miniaturization and parallel processing play an important role in the evolution of many
technologies. We demonstrate the application of miniaturized high-throughput …

A highly stereocontrolled synthesis of tetrasubstituted acyclic all-carbon olefins has been
developed via a stereoselective enolization and tosylate formation, followed by a palladium …

The Catalysis Laboratory at Merck was established in 2002 to discover and develop
asymmetric hydrogenation transformations for application to the company's pipeline. Twenty …