Neurofilament proteins as biomarkers to monitor neurological diseases and the efficacy of therapies

A Yuan, RA Nixon - Frontiers in neuroscience, 2021 - frontiersin.org
Biomarkers of neurodegeneration and neuronal injury have the potential to improve
diagnostic accuracy, disease monitoring, prognosis, and measure treatment efficacy …

Neurofilaments and neurofilament proteins in health and disease

A Yuan, MV Rao, RA Nixon - Cold Spring Harbor …, 2017 - cshperspectives.cshlp.org
Neurofilaments (NFs) are unique among tissue-specific classes of intermediate filaments
(IFs) in being heteropolymers composed of four subunits (NF-L [neurofilament light]; NF-M …

Increased neurofilament light chain blood levels in neurodegenerative neurological diseases

J Gaiottino, N Norgren, R Dobson, J Topping, A Nissim… - PloS one, 2013 - journals.plos.org
Objective Neuronal damage is the morphological substrate of persisting neurological
disability. Neurofilaments (Nf) are cytoskeletal proteins of neurons and their release into …

Serum neurofilament is associated with progression of brain atrophy and disability in early MS

J Kuhle, B Nourbakhsh, D Grant, S Morant, C Barro… - Neurology, 2017 - AAN Enterprises
Objective: To investigate a potential effect of riluzole on serum neurofilaments (Nf) compared
to placebo and the relationship between longitudinal clinical and MRI outcomes and serum …

Comprehensive characterization and failure modes of tungsten microwire arrays in chronic neural implants

A Prasad, QS Xue, V Sankar, T Nishida… - Journal of neural …, 2012 - iopscience.iop.org
For nearly 55 years, tungsten microwires have been widely used in neurophysiological
experiments in animal models to chronically record neuronal activity. While tungsten …

Brain neurotrauma: molecular, neuropsychological, and rehabilitation aspects

FH Kobeissy - 2015 - books.google.com
With the contribution from more than one hundred CNS neurotrauma experts, this book
provides a comprehensive and up-to-date account on the latest developments in the area of …

Diagnostic and prognostic performance of neurofilaments in ALS

K Poesen, P Van Damme - Frontiers in neurology, 2019 - frontiersin.org
There is a need for biomarkers for amyotrophic lateral sclerosis (ALS), to support the
diagnosis of the disease, to predict disease progression and to track disease activity and …

Serum neurofilament light chain is a biomarker of human spinal cord injury severity and outcome

J Kuhle, J Gaiottino, D Leppert, A Petzold… - Journal of Neurology …, 2015 - jnnp.bmj.com
Background Neurofilaments (Nf) are major structural proteins that occur exclusively in
neurons. In spinal cord injury (SCI), the severity of disease is quantified by clinical measures …

[图书][B] The handbook of biomarkers

KK Jain, KK Jain - 2010 - Springer
There are several definitions of biomarkers. A biomarker is a characteristic that can be
objectively measured and evaluated as an indicator of a physiological as well as a …

[HTML][HTML] Morphologic features and glial activation in rat oxaliplatin-dependent neuropathic pain

LDC Mannelli, A Pacini, L Bonaccini, M Zanardelli… - The Journal of …, 2013 - Elsevier
Neurotoxicity is the limiting side effect of the anticancer agent oxaliplatin. A tangled panel of
symptoms, sensory loss, paresthesia, dysesthesia, and pain may be disabling for patients …