A systematic review of the global intervention for SARS-CoV-2 combating: from drugs repurposing to molnupiravir approval
NA Ashour, A Abo Elmaaty, AA Sarhan… - Drug design …, 2023 - Taylor & Francis
The rising outbreak of SARS-CoV-2 continues to unfold all over the world. The development
of novel effective antiviral drugs to fight against SARS-CoV-2 is a time cost. As a result, some …
of novel effective antiviral drugs to fight against SARS-CoV-2 is a time cost. As a result, some …
Efficacy and safety of dihydroorotate dehydrogenase (DHODH) inhibitors “leflunomide” and “teriflunomide” in Covid-19: A narrative review
Dihydroorotate dehydrogenase (DHODH) is rate-limiting enzyme in biosynthesis of
pyrimidone which catalyzes the oxidation of dihydro-orotate to orotate. Orotate is utilized in …
pyrimidone which catalyzes the oxidation of dihydro-orotate to orotate. Orotate is utilized in …
Multi-omics-based identification of SARS-CoV-2 infection biology and candidate drugs against COVID-19
SARS-CoV-2 has ushered a global pandemic with no effective drug being available at
present. Although several FDA-approved drugs are currently under clinical trials for drug …
present. Although several FDA-approved drugs are currently under clinical trials for drug …
A review of COVID-19 biomarkers and drug targets: resources and tools
The stratification of patients at risk of progression of COVID-19 and their molecular
characterization is of extreme importance to optimize treatment and to identify therapeutic …
characterization is of extreme importance to optimize treatment and to identify therapeutic …
Weakly activated core neuroinflammation pathways were identified as a central signaling mechanism contributing to the chronic neurodegeneration in Alzheimer's …
F Li, AM Eteleeb, W Buchser, C Sohn… - Frontiers in Aging …, 2022 - frontiersin.org
Objectives Neuroinflammation signaling has been identified as an important hallmark of
Alzheimer's disease (AD) in addition to amyloid β plaques (Aβ) and neurofibrillary tangles …
Alzheimer's disease (AD) in addition to amyloid β plaques (Aβ) and neurofibrillary tangles …
Clomipramine suppresses ACE2-mediated SARS-CoV-2 entry
Y Kato, S Yamada, K Nishiyama, A Satsuka, S Re… - bioRxiv, 2021 - biorxiv.org
Myocardial damage caused by the newly emerged coronavirus (SARS-CoV-2) infection is
one of key determinants of COVID-19 severity and mortality. SARS-CoV-2 entry to host cells …
one of key determinants of COVID-19 severity and mortality. SARS-CoV-2 entry to host cells …
Defeating the COVID-19 Pandemic by Targeting the Critical Interface between SARS-CoV-2 Virus Infection andIts DestructiveImmune System Effects
S Crawford - Medical Research Archives, 2020 - esmed.org
Having recently made the evolutionary transition from bats to humans, the novel
Coronavirus SARS-Cov-2 has single-handedly created a defining moment in human history …
Coronavirus SARS-Cov-2 has single-handedly created a defining moment in human history …