Opioids and the blood-brain barrier: a dynamic interaction with consequences on drug disposition in brain
C Chaves, F Remiao, S Cisternino… - Current …, 2017 - ingentaconnect.com
Background: Opioids are widely used in pain management, acting via opioid receptors
and/or Toll-like receptors (TLR) present at the central nervous system (CNS). At the blood …
and/or Toll-like receptors (TLR) present at the central nervous system (CNS). At the blood …
Contribution of gut microbiota to immunological changes in Alzheimer's disease
L van Olst, SJM Roks, A Kamermans… - Frontiers in …, 2021 - frontiersin.org
Emerging evidence suggests that both central and peripheral immunological processes play
an important role in the pathogenesis of Alzheimer's disease (AD), but regulatory …
an important role in the pathogenesis of Alzheimer's disease (AD), but regulatory …
Dextran sulfate sodium-induced colitis and ginseng intervention altered oral pharmacokinetics of cyclosporine A in rats
Y Yang, N Hu, XJ Gao, T Li, ZX Yan, PP Wang… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Application of cyclosporine A (CsA) as a rescue treatment
in acute severe ulcerative colitis (UC) is limited by its narrow therapeutic window and great …
in acute severe ulcerative colitis (UC) is limited by its narrow therapeutic window and great …
Obesity and altered aspirin pharmacology
NB Norgard - Clinical pharmacokinetics, 2018 - Springer
Obesity is an independent risk factor for cardiovascular morbidity and mortality due to
atherothrombotic events and represents a group of patients who are in need of optimized …
atherothrombotic events and represents a group of patients who are in need of optimized …
Streptococcus agalactiae disrupts P-glycoprotein function in brain endothelial cells
BJ Kim, MA McDonagh, L Deng, BD Gastfriend… - Fluids and Barriers of …, 2019 - Springer
Bacterial meningitis is a serious life threatening infection of the CNS. To cause meningitis,
blood–borne bacteria need to interact with and penetrate brain endothelial cells (BECs) that …
blood–borne bacteria need to interact with and penetrate brain endothelial cells (BECs) that …
MiR-138 indirectly regulates the MDR1 promoter by NF-κB/p65 silencing
JL Requenez-Contreras, ES López-Castillejos… - Biochemical and …, 2017 - Elsevier
MicroRNAs (miRNAs) are known to mediate post-transcriptional gene silencing in the
cytoplasm and recent evidence indicates that may also possess nuclear roles in regulating …
cytoplasm and recent evidence indicates that may also possess nuclear roles in regulating …
Cytotoxicity and preliminary mode of action studies of novel 2-aryl-4-thiopyrone-based organometallics
M Schmidlehner, LS Flocke, A Roller, M Hejl… - Dalton …, 2016 - pubs.rsc.org
Organometallic complexes with thiopyrone-based ligands have shown promising cytotoxic
activity in vitro. To investigate the impact of the ligand backbone modification of these …
activity in vitro. To investigate the impact of the ligand backbone modification of these …
Acute regulation of apical ABC transporters in the gut. Potential influence on drug bioavailability
CJ Domínguez, GN Tocchetti, JP Rigalli… - Pharmacological …, 2021 - Elsevier
The extensive intestinal surface offers an advantage regarding nutrient, ion and water
absorptive capacity but also brings along a high exposition to xenobiotics, including drugs of …
absorptive capacity but also brings along a high exposition to xenobiotics, including drugs of …
Pharmacokinetics of fexofenadine following LPS administration to rats
The function and expression of drug transporters, including P-glycoprotein (P-gp) and
organic-anion transporting polypeptides (Oatps), have been investigated but it is not well …
organic-anion transporting polypeptides (Oatps), have been investigated but it is not well …
Obesity and inflammation and altered clopidogrel pharmacokinetics and pharmacodynamics
NB Norgard, SV Monte - Drug Metabolism Letters, 2017 - ingentaconnect.com
Background: Clopidogrel is a key antiplatelet drug that has substantial interpatient variability
in pharmacodynamic response. Patients with lesser degrees of platelet inhibition in …
in pharmacodynamic response. Patients with lesser degrees of platelet inhibition in …