As a critical component of the tumor microenvironment (TME), cancer‐associated fibroblasts
(CAFs) play important roles in cancer initiation and progression. Well‐known signaling …

Colorectal cancer (CRC) is one of the leading causes of mortality among cancers. Many
aspects of this cancer are under investigation to find established markers of diagnosis …

Integrins, a group of heterodimer receptors for cell-matrix and cell-cell adhesion, mediate
various intracellular activities, including cell migration, polarity, survival, growth, and death …

Abstract Background Integrin β4 (ITGB4) participates in tumorigenesis and progression of
several malignancies, but its role and related mechanisms in clear cell renal cell carcinoma …

Colorectal cancer (CRC) is among the topmost malignancies for both genders. Despite the
high incidence rate and advances in diagnostic tools, treatment in many cases is still …

Abstract Integrinβ-1 (ITGB1) is a crucial member of the transmembrane glycoprotein
signaling receptor family and is also central to the integrin family. It forms heterodimers with …

Adhesion molecules mediate cell-to-cell and cell-to-extracellular matrix interactions and
transmit mechanical and chemical signals among them. Various mechanisms deregulate …

Simple Summary Gastrointestinal (GI) cancers are the leading cancer-related deaths
worldwide. Despite improved survival rates with current treatments, recurrence remains a …

Developmental dysplasia of the hip (DDH) is characterized by anatomical abnormalities of
the hip joint, ranging from mild acetabular dysplasia to hip subluxation and eventually …

Integrins are a large family of heterodimeric transmembrane receptors which mediate cell
adhesion and transmit signals to the cell interior. The mechanistic roles of integrins have …