Machine learning-enabled cancer diagnostics with widefield polarimetric second-harmonic generation microscopy

K Mirsanaye, L Uribe Castaño, Y Kamaliddin… - Scientific reports, 2022 - nature.com
The extracellular matrix (ECM) collagen undergoes major remodeling during tumorigenesis.
However, alterations to the ECM are not widely considered in cancer diagnostics, due to …

Unsupervised determination of lung tumor margin with widefield polarimetric second-harmonic generation microscopy

K Mirsanaye, L Uribe Castaño, Y Kamaliddin… - Scientific Reports, 2022 - nature.com
The extracellular matrix (ECM) is amongst many tissue components affected by cancer,
however, morphological changes of the ECM are not well-understood and thus, often …

Application of Ultrashort Lasers in Developmental Biology: A Review

IV Ilina, DS Sitnikov - Photonics, 2022 - mdpi.com
The evolution of laser technologies and the invention of ultrashort laser pulses have resulted
in a sharp jump in laser applications in life sciences. Developmental biology is no exception …

Wide‐field Stokes polarimetric microscopy for second harmonic generation imaging

L Uribe Castaño, K Mirsanaye, L Kontenis… - Journal of …, 2023 - Wiley Online Library
We employ wide‐field second harmonic generation (SHG) microscopy together with
nonlinear Stokes polarimetry for quick ultrastructural investigation of large sample areas …

Second Harmonic Generation Properties in Chiral Sarcomeres of Drosophila Larval Muscles

A Karunendiran, K Mirsanaye, BA Stewart… - Frontiers in …, 2022 - frontiersin.org
Polarimetric second harmonic generation (SHG) microscopy is a label-free ultrastructural
imaging technique that is applied to study molecular organization in striated muscle …

Polarimetric second harmonic generation microscopy of partially oriented fibers II: Imaging study

M Alizadeh, F Habach, M Maciulis, L Kontenis… - Biophysical …, 2023 - cell.com
Polarimetric second harmonic generation (SHG) microscopy imaging is employed to
investigate the ultrastructural organization of biological and biomimetic partially oriented …

Study of the spatial scale stability of Mueller matrix parameters for textural characterization of biological tissues

Y Chen, J Chu, WC Tang, R Zhang… - Journal of …, 2022 - Wiley Online Library
Mueller matrix imaging polarimetry (MMIP) is a promising technique for the textural
characterization of biological tissue structures. To reveal the influence of imaging …

Wide-field multicontrast nonlinear microscopy for histopathology

LU Castaño, K Mirsanaye, A Golaraei, L Kontenis… - bioRxiv, 2022 - biorxiv.org
A multicontrast polarimetric wide-field second harmonic generation (SHG) and multiphoton
excitation fluorescence (MPF) microscope is optimized for large area imaging of hematoxylin …

Polarization-resolved SHG microscopy for biomedical applications

R Cisek, MA Harvey, E Bennett, H Jeon… - … Polarimetric Modalities for …, 2023 - Springer
Polarization-resolved second harmonic generation (PSHG) microscopy is a powerful
technique capable of differentiating biological tissues as well as determining ultrastructural …

Polarimetric response of second harmonic generation in microscopy of chiral fibrillar structures

M Alizadeh, F Habach, M Maciulis, L Kontenis… - bioRxiv, 2023 - biorxiv.org
Polarimetric second harmonic generation (SHG) microscopy is employed to study partially
oriented fibrillar structures. The polarimetric SHG parameters are influenced by three …