New developments in RiPP discovery, enzymology and engineering

M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

[HTML][HTML] A review of hybrid renewable energy systems in mini-grids for off-grid electrification in developing countries

EIC Zebra, HJ van der Windt, G Nhumaio… - … and Sustainable Energy …, 2021 - Elsevier
Rural communities in developing countries lack access to affordable, reliable, and
sustainable forms of energy, which are essential factors for improving living conditions …

[PDF][PDF] After a century of nisin research-where are we now?

D Field, M Fernandez de Ullivarri… - FEMS microbiology …, 2023 - academic.oup.com
It is almost a century since nisin was discovered in fermented milk cultures, coincidentally in
the same year that penicillin was first described. Over the last 100 years this small, highly …

Increasing the antimicrobial activity of nisin-based lantibiotics against Gram-negative pathogens

Q Li, M Montalban-Lopez… - Applied and environmental …, 2018 - Am Soc Microbiol
Lantibiotics are ribosomally synthesized and posttranslationally modified antimicrobial
compounds containing lanthionine and methyl-lanthionine residues. Nisin, one of the most …

Lipidated variants of the antimicrobial peptide nisin produced via incorporation of methionine analogs for click chemistry show improved bioactivity

L Guo, C Wang, J Broos, OP Kuipers - Journal of Biological Chemistry, 2023 - ASBMB
The increase in antibiotic resistance calls for accelerated molecular engineering strategies
to diversify natural products for drug discovery. The incorporation of non-canonical amino …

Analysis of modular bioengineered antimicrobial lanthipeptides at nanoliter scale

S Schmitt, M Montalbán-López, D Peterhoff… - Nature chemical …, 2019 - nature.com
The rise of antibiotic resistance demands the acceleration of molecular diversification
strategies to inspire new chemical entities for antibiotic medicines. We report here on the …

Therapeutic application of lantibiotics and other lanthipeptides: old and new findings

ADP van Staden, WF van Zyl, M Trindade… - Applied and …, 2021 - Am Soc Microbiol
Lanthipeptides are ribosomally synthesized and posttranslationally modified peptides, with
modifications that are incorporated during biosynthesis by dedicated enzymes. Various …

Rombocin, a Short Stable Natural Nisin Variant, Displays Selective Antimicrobial Activity against Listeria monocytogenes and Employs a Dual Mode of Action to Kill …

L Guo, J Wambui, C Wang, J Broos… - ACS Synthetic …, 2024 - ACS Publications
Nisin, with its unique mode of action and potent antimicrobial activity, serves as a
remarkable inspiration for the design of novel antibiotics. However, peptides possess …

Cesin, a short natural variant of nisin, displays potent antimicrobial activity against major pathogens despite lacking two C-terminal macrocycles

L Guo, J Wambui, C Wang, F Muchaamba… - Microbiology …, 2023 - Am Soc Microbiol
Nisin is a widely used lantibiotic owing to its potent antimicrobial activity and its food-grade
status. Its mode of action includes cell wall synthesis inhibition and pore formation, which …

Nisin S, a Novel Nisin Variant Produced by Ligilactobacillus salivarius P1CEA3

E Sevillano, N Peña, I Lafuente, LM Cintas… - International journal of …, 2023 - mdpi.com
Recently, the food industry and the animal farming field have been working on different
strategies to reduce the use of antibiotics in animal production. The use of probiotic …