Over the past decades, a number of 1, 4‐naphthoquinones have been isolated from natural
resources and several of naphthoquinone derivatives with diverse structural motif have been …

This book describes a unique class of secondary metabolites, the mono-and dimeric
naphthylisoquinoline alkaloids. They occur in lianas of the paleotropical Ancistrocladaceae …

Malaria can be caused by several Plasmodium species and the development of an effective
vaccine is challenging. Currently, the most effective tool to control the disease is the …

Background Chagas disease, also known as American Trypanosomiasis, is caused by the
protozoan Trypanosoma cruzi. It is occurring in Americas, including USA and Canada, and …

Abstract According to the World Health Organization, leishmaniasis is considered as a major
neglected tropical disease causing an enormous impact on global public health. Available …

Thirty four halogen and selenium-containing quinones, synthesized by rhodium-catalyzed
CH bond activation and palladium-catalyzed cross-coupling reactions, were evaluated …

Natural products comprise valuable sources for new antiparasitic drugs. Here we tested the
effects of a novel β–lapachone derivative on Trypanosoma cruzi parasite survival and …

Currently the only drug available to treat Chagas disease in Brazil is benznidazole (BZN).
Therefore, there is an urgent need to discover and develop new anti-Trypanosoma cruzi …

It is estimated that the worldwide prevalence of leishmaniasis is around 12 million
individuals in 80 countries, with 400,000 new cases per year. In the search for new …

Current treatments for leishmaniasis present some difficulties due to their toxicity, the use of
the intravenous route for administration and therapy duration, which may lead to treatment …