Highlights•Epitope vaccines provide maximal therapeutic efficacy with minimal side
effects.•Reverse vaccinology can be used for designing epitope vaccines.•Computational …

Highlights•The mRNA-based vaccines are tunable quality-by-design immunotherapy
modalities for different diseases.•Self-amplifying mRNA (saRNA) vaccines, a kind of mRNA …

Methods: In this study, we have targeted spike (S) glycoprotein, as an important surface
antigen to identify its B-and T-cell immunodominant regions. We have conducted a multi …

All the time, echinococcosis is a global zoonotic disease which seriously endangers public
health all over the world. In order to speed up the development process of anti …

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Introduction: Hydatid disease is a ubiquitous parasitic zoonotic disease, which causes …

Introduction: Triple-negative breast cancer (TNBC) is an important subtype of breast cancer,
which occurs in the absence of estrogen, progesterone and HER-2 receptors. According to …

Protein-peptide interactions have attracted the attention of many drug discovery scientists
due to their possible druggability features on most key biological activities such as …

Brucellosis is one of the most serious and widespread zoonotic diseases, which seriously
threatens human health and the national economy. This study was based on the T/B …

Most of the recent approved therapeutic proteins are multi-subunit biologics, which need
glycosylation and disulfide bridges for their correct conformation and biological functions …

Vaccines have significantly reduced the impact of numerous deadly viral infections.
However, there is an increasing need to expedite vaccine development in light of the …