Sensory photoreceptors underpin light-dependent adaptations of organismal physiology,
development, and behavior in nature. Adapted for optogenetics, sensory photoreceptors …

Light-controllable tools provide powerful means to manipulate and interrogate brain function
with relatively low invasiveness and high spatiotemporal precision. Although optogenetic …

Optogenetics combines light and genetics to enable precise control of living cells, tissues,
and organisms with tailored functions. Optogenetics has the advantages of …

Cell and gene therapies hold tremendous promise for treating a range of difficult-to-treat
diseases. However, concerns over the safety and efficacy require to be further addressed in …

Optobiochemical control of protein activities allows the investigation of protein functions in
living cells with high spatiotemporal resolution. Over the last two decades, numerous natural …

Strategies for eradicating cancer stem cells (CSCs) are urgently required because CSCs are
resistant to anticancer drugs and cause treatment failure, relapse and metastasis. Here, we …

The Ca2+ release-activated Ca2+ (CRAC) channels control many Ca2+-modulated
physiological processes in mammals. Hyperactivating CRAC channels are known to cause …

Membrane ion channels are ultimately responsible for the propagation and integration of
electrical signals in the nervous, muscular, and other systems. Their activation or …

Neuroregeneration is a dynamic process synergizing the functional outcomes of multiple
signaling circuits. Channelrhodopsin-based optogenetics shows the feasibility of stimulating …

Highlights•Overview of optogenetic tools to control Ca 2+-modulated physiological
processes.•Engineering strategies for genetically encoded Ca 2+ channel actuators …