In physiological hemostasis a prompt recruitment of platelets on the vessel damage prevents
the bleeding by the rapid formation of a platelet plug. Qualitative and/or quantitative platelet …

Although rare, the prevalence of inherited platelet function disorders (IPFD) is probably
underestimated due to under‐diagnosis 1. IPFD are heterogeneous in severity, mechanisms …

The demand for platelets in England was stable at around 220,000 adult therapeutic doses
(ATD) per year until 2007/8 at which point demand has increased year on year to 275,000 …

Platelet-driven blood clot contraction (retraction) is thought to promote wound closure and
secure hemostasis while preventing vascular occlusion. Notwithstanding its importance, clot …

Platelet function testing is important for the diagnostic evaluation of common and rare
bleeding disorders. Our study goals were to promote best practices and reduce unnecessary …

Genetic defects of the megakaryocyte lineage give rise to bleeding syndromes of varying
severity. Blood platelets are unable to fulfill their hemostatic function of preventing blood loss …

The contribution of platelets to normal hemostasis and vascular disease is well described.
However, recent studies make it clear that much remains to be learned about platelet …

Background: Light transmission aggregometry (LTA) is commonly performed to assess
individuals for bleeding disorders. Objectives: The goal was to evaluate the incidence and …

Light transmission aggregometry (LTA) is used worldwide for the investigation of heritable
platelet function disorders (PFDs), but interpretation of results is complicated by the …

Severe platelet function defects are rare disorders that require expertise in diagnosis and
management. Therefore patients with such disorders should be referred to and managed in …