Alterations in the cell-cycle regulatory genes result in uncontrolled cell proliferation leading
to several disease conditions. Cyclin-dependent kinases (CDK) and their regulatory subunit …

Cell division cycle 25 A (Cdc25A), a dual-specificity protein phosphatase, is one of the most
crucial cell cycle regulators, which removes the inhibitory phosphorylation in cyclin …

Phosphatases are crucially involved in cellular processes by dephosphorylating cellular
components. We describe a structure-based classification scheme for all active human …

Here, we will review the evidence showing that mitotic exit is initiated by regulated
proteolysis and then driven by the PPP family of phosphoserine/threonine phosphatases …

Aberrant protein phosphorylation is one of the hallmarks of cancer cells, and in many cases
a prerequisite to sustain tumor development and progression. Like protein kinases, protein …

Chk1 (encoded by CHEK1 in mammals) is an evolutionarily conserved protein kinase that
transduces checkpoint signals from ATR to Cdc25A during the DNA damage response …

Cancer is known as one of the leading causes of human deaths globally. Late diagnosis is
considered as one of the main reasons for the high mortality rate among cancer patients …

Polyploid giant cancer cells (PGCCs) are key contributors to cancer heterogeneity, and the
formation of PGCCs is associated with changes in the expression of cell-cycle-related …

Over the past decade Hippo kinase signalling has been established as an essential tumour
suppressor pathway controlling tissue growth in flies and mammals. All members of the …

HIV-1 is extremely specialized since, even amongst CD4+ T lymphocytes (its major natural
reservoir in peripheral blood), the virus productively infects only a small proportion of cells …