Potent acetylcholinesterase inhibitors: potential drugs for Alzheimer's disease
H Akıncıoğlu, İ Gülçin - Mini reviews in medicinal chemistry, 2020 - ingentaconnect.com
Alzheimer's disease (AD) is one of the cognitive or memory-related impairments occurring
with advancing age. Since its exact mechanism is not known, the full therapy has still not …
with advancing age. Since its exact mechanism is not known, the full therapy has still not …
Phenolic compounds as antioxidants: carbonic anhydrase isoenzymes inhibitors
I Gulcin, S Beydemir - Mini reviews in medicinal chemistry, 2013 - ingentaconnect.com
Antioxidant compounds can scavenge free radicals and increase shelf life by retarding the
process of lipid peroxidation, which is one of the major reasons for deterioration of food …
process of lipid peroxidation, which is one of the major reasons for deterioration of food …
Methods to evaluate the scavenging activity of antioxidants toward reactive oxygen and nitrogen species (IUPAC Technical Report)
R Apak, A Calokerinos, S Gorinstein… - Pure and Applied …, 2022 - degruyter.com
This project was aimed to identify the quenching chemistry of biologically important reactive
oxygen and nitrogen species (ROS/RNS, including radicals), to show antioxidant action …
oxygen and nitrogen species (ROS/RNS, including radicals), to show antioxidant action …
Synthesis and carbonic anhydrase isoenzymes I, II, IX, and XII inhibitory effects of dimethoxybromophenol derivatives incorporating cyclopropane moieties
M Boztas, Y Cetinkaya, M Topal, I Gulcin… - Journal of medicinal …, 2015 - ACS Publications
Cyclopropylcarboxylic acids and esters and cyclopropylmethanols incorporating
bromophenol moieties were investigated as inhibitors of the carbonic anhydrase enzyme …
bromophenol moieties were investigated as inhibitors of the carbonic anhydrase enzyme …
The effect of caffeic acid phenethyl ester (CAPE) on metabolic enzymes including acetylcholinesterase, butyrylcholinesterase, glutathione S-transferase …
Caffeic acid phenethyl ester (CAPE) is an active component of honeybee propolis extracts.
Carbonic anhydrases (CAs, EC 4.2. 1.1) are widespread and intensively studied …
Carbonic anhydrases (CAs, EC 4.2. 1.1) are widespread and intensively studied …
Antidiabetic potential: in vitro inhibition effects of some natural phenolic compounds on α‐glycosidase and α‐amylase enzymes
P Taslimi, İ Gulçin - Journal of Biochemical and Molecular …, 2017 - Wiley Online Library
Abstract α‐Glycosidase is a catalytic enzyme and it destroys the complex carbohydrates into
simple absorbable sugar units. The natural phenolic compounds were tested for their …
simple absorbable sugar units. The natural phenolic compounds were tested for their …
Acetylcholinesterase and carbonic anhydrase inhibitory properties of novel urea and sulfamide derivatives incorporating dopaminergic 2-aminotetralin scaffolds
In the present study a series of urea and sulfamide compounds incorporating the tetralin
scaffolds were synthesized and evaluated for their acetylcholinesterase (AChE), human …
scaffolds were synthesized and evaluated for their acetylcholinesterase (AChE), human …
Antioxidant, antiradical, and anticholinergic properties of cynarin purified from the Illyrian thistle (Onopordum illyricum L.)
Cynarin is a derivative of hydroxycinnamic acid and it has biologically active functional
groups constituent of some plants and food. We elucidated the antioxidant activity of cynarin …
groups constituent of some plants and food. We elucidated the antioxidant activity of cynarin …
Calcium channel blockers: molecular docking and inhibition studies on carbonic anhydrase I and II isoenzymes
C Türkeş, Y Demir, Ş Beydemir - Journal of Biomolecular Structure …, 2021 - Taylor & Francis
Carbonic anhydrases (CAs) are potent dehydration of carbonic acid and catalyst of the
reversible hydration of carbon dioxide. Here, CA I and CA II was purified from human …
reversible hydration of carbon dioxide. Here, CA I and CA II was purified from human …
Antibiofilm and Anti-Quorum-Sensing Activities of Novel Pyrazole and Pyrazolo[1,5-a]pyrimidine Derivatives as Carbonic Anhydrase I and II Inhibitors: Design …
A Ragab, SA Fouad, YA Ammar, DS Aboul-Magd… - Antibiotics, 2023 - mdpi.com
Nowadays, searching for new anti-infective agents with diverse mechanisms of action has
become necessary. In this study, 16 pyrazole and pyrazolo [1, 5-a] pyrimidine derivatives …
become necessary. In this study, 16 pyrazole and pyrazolo [1, 5-a] pyrimidine derivatives …