The landscape of tolerated genetic variation in humans and primates
H Gao, T Hamp, J Ede, JG Schraiber, J McRae… - Science, 2023 - science.org
Personalized genome sequencing has revealed millions of genetic differences between
individuals, but our understanding of their clinical relevance remains largely incomplete. To …
individuals, but our understanding of their clinical relevance remains largely incomplete. To …
[HTML][HTML] The evolution of aging and lifespan
S Li, JM Vazquez, PH Sudmant - Trends in Genetics, 2023 - cell.com
Aging is a nearly inescapable trait among organisms yet lifespan varies tremendously
across different species and spans several orders of magnitude in vertebrates alone. This …
across different species and spans several orders of magnitude in vertebrates alone. This …
[PDF][PDF] Genome annotation: From human genetics to biodiversity genomics
R Guigó - Cell Genomics, 2023 - cell.com
Within the next decade, the genomes of 1.8 million eukaryotic species will be sequenced.
Identifying genes in these sequences is essential to understand the biology of the species …
Identifying genes in these sequences is essential to understand the biology of the species …
Identification of constrained sequence elements across 239 primate genomes
Noncoding DNA is central to our understanding of human gene regulation and complex
diseases,, and measuring the evolutionary sequence constraint can establish the functional …
diseases,, and measuring the evolutionary sequence constraint can establish the functional …
Local energetic frustration conservation in protein families and superfamilies
Energetic local frustration offers a biophysical perspective to interpret the effects of
sequence variability on protein families. Here we present a methodology to analyze local …
sequence variability on protein families. Here we present a methodology to analyze local …
On the genetic basis of tail-loss evolution in humans and apes
The loss of the tail is among the most notable anatomical changes to have occurred along
the evolutionary lineage leading to humans and to the 'anthropomorphous apes',–, with a …
the evolutionary lineage leading to humans and to the 'anthropomorphous apes',–, with a …
Two hundred and five newly assembled mitogenomes provide mixed evidence for rivers as drivers of speciation for Amazonian primates
Mitochondrial DNA remains a cornerstone for molecular ecology, especially for study
species from which high‐quality tissue samples cannot be easily obtained. Methods using …
species from which high‐quality tissue samples cannot be easily obtained. Methods using …
CADD v1. 7: using protein language models, regulatory CNNs and other nucleotide-level scores to improve genome-wide variant predictions
M Schubach, T Maass, L Nazaretyan… - Nucleic Acids …, 2024 - academic.oup.com
Abstract Machine Learning-based scoring and classification of genetic variants aids the
assessment of clinical findings and is employed to prioritize variants in diverse genetic …
assessment of clinical findings and is employed to prioritize variants in diverse genetic …
Self-supervised learning on millions of primary RNA sequences from 72 vertebrates improves sequence-based RNA splicing prediction
Abstract Language models pretrained by self-supervised learning (SSL) have been widely
utilized to study protein sequences, while few models were developed for genomic …
utilized to study protein sequences, while few models were developed for genomic …
Did the human genome project affect research on Schizophrenia?
EF Torrey - Psychiatry Research, 2024 - Elsevier
Abstract The Human Genome Project was undertaken primarily to discover genetic causes
and better treatments for human diseases. Schizophrenia was targeted since three of the …
and better treatments for human diseases. Schizophrenia was targeted since three of the …