[HTML][HTML] Biocatalysis

EL Bell, W Finnigan, SP France, AP Green… - Nature Reviews …, 2021 - nature.com
Biocatalysis has become an important aspect of modern organic synthesis, both in
academia and across the chemical and pharmaceutical industries. Its success has been …

Homology modeling in drug discovery: Overview, current applications, and future perspectives

MT Muhammed, E Aki‐Yalcin - Chemical biology & drug design, 2019 - Wiley Online Library
Homology modeling is one of the computational structure prediction methods that are used
to determine protein 3D structure from its amino acid sequence. It is considered to be the …

[HTML][HTML] A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19

Y Zhou, Y Hou, J Shen, R Mehra, A Kallianpur… - PLoS …, 2020 - journals.plos.org
The global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to unprecedented social and …

PubChem substance and compound databases

S Kim, PA Thiessen, EE Bolton, J Chen… - Nucleic acids …, 2016 - academic.oup.com
Abstract PubChem (https://pubchem. ncbi. nlm. nih. gov) is a public repository for information
on chemical substances and their biological activities, launched in 2004 as a component of …

Beta-lactamase database (BLDB)–structure and function

T Naas, S Oueslati, RA Bonnin, ML Dabos… - Journal of enzyme …, 2017 - Taylor & Francis
Abstract Beta-Lactamase Database (BLDB) is a comprehensive, manually curated public
resource providing up-to-date structural and functional information focused on this …

Co-occurrence of resistance genes to antibiotics, biocides and metals reveals novel insights into their co-selection potential

C Pal, J Bengtsson-Palme, E Kristiansson… - BMC genomics, 2015 - Springer
Background Antibacterial biocides and metals can co-select for antibiotic resistance when
bacteria harbour resistance or tolerance genes towards both types of compounds. Despite …

New insights into the function and global distribution of polyethylene terephthalate (PET)-degrading bacteria and enzymes in marine and terrestrial metagenomes

D Danso, C Schmeisser, J Chow… - Applied and …, 2018 - Am Soc Microbiol
Polyethylene terephthalate (PET) is one of the most important synthetic polymers used
today. Unfortunately, the polymers accumulate in nature and to date no highly active …

Neuronal APOE4 removal protects against tau-mediated gliosis, neurodegeneration and myelin deficits

N Koutsodendris, J Blumenfeld, A Agrawal, M Traglia… - Nature aging, 2023 - nature.com
Abstract Apolipoprotein E4 (APOE4) is the strongest known genetic risk factor for late-onset
Alzheimer's disease (AD). Conditions of stress or injury induce APOE expression within …

Handheld point-of-care system for rapid detection of SARS-CoV-2 extracted RNA in under 20 min

J Rodriguez-Manzano… - ACS central …, 2021 - ACS Publications
The COVID-19 pandemic is a global health emergency characterized by the high rate of
transmission and ongoing increase of cases globally. Rapid point-of-care (PoC) diagnostics …

The UCSC genome browser database: 2017 update

C Tyner, GP Barber, J Casper, H Clawson… - Nucleic acids …, 2017 - academic.oup.com
Since its 2001 debut, the University of California, Santa Cruz (UCSC) Genome Browser
(http://genome. ucsc. edu/) team has provided continuous support to the international …