Impaired mitochondrial function often results in excessive production of reactive oxygen
species (ROS) and is involved in the etiology of many chronic diseases, including …

The direct effects of physical activity interventions on energy expenditure are relatively small
when placed in the context of total daily energy demands. Hence, the suggestion has been …

We tested the hypothesis of a lower respiratory capacity per mitochondrion in skeletal
muscle of type 2 diabetic patients compared with obese subjects. Muscle biopsies obtained …

The peroxisome proliferator-activated receptor (PPAR)-γ coactivator-1 (PGC-1) can induce
mitochondria biogenesis and has been implicated in the development of oxidative type I …

Recent evidence points toward decreased oxidative capacity and mitochondrial aberrations
as a major contributor to the development of insulin resistance and type 2 diabetes. In this …

Despite its crucial importance, scientists interested in the limitations of human physical
performance have only just started to give the field of oxygen uptake kinetics the attention it …

This study was designed to determine the histological and metabolic effects of the
administration of 5′-AMP-activated protein kinase (AMPK) activator 5-aminoimidazole-4 …

Mitochondria are the primary source of energy production and are implicated in a wide
range of biological processes in most eukaryotic cells. Skeletal muscle heavily relies on …

We studied the effect of an alteration from regular endurance to speed endurance training
on muscle oxidative capacity, capillarization, as well as energy expenditure during …

The purpose of this study was to investigate the hypothesis that cycling efficiency in vivo is
related to mitochondrial efficiency measured in vitro and to investigate the effect of training …