The amphetamine derivative (±)-3, 4-methylenedioxymethamphetamine (MDMA, ecstasy) is
a popular recreational drug among young people, particularly those involved in the dance …

G protein-coupled receptors (GPCRs) represent the largest family of cell-surface receptors.
These receptors are natural allosteric proteins because agonist-mediated signaling by …

Examples of G-protein-coupled receptors that can be biochemically detected in homo-or
heteromeric complexes are emerging at an accelerated rate. Biophysical approaches have …

G-protein-coupled receptors (GPCRs) 1 constitute a large superfamily of receptor proteins
responsible for signal transduction (see http://www. gpcr. org/7tm). Throughout all higher …

The molecular basis for the known intramembrane receptor/receptor interactions among G
protein-coupled receptors was postulated to be heteromerization based on receptor subtype …

The existence of A 2A-D 2 heteromeric complexes is based on coimmunoprecipitation
studies and on fluorescence resonance energy transfer and bioluminescence resonance …

G-protein-coupled receptors (GPCRs) comprise the largest family of transmembrane
receptors in the human genome that respond to a plethora of signals, including …

CXCR4, a member of the G protein-coupled receptor family of proteins, is the receptor for
stromal cell-derived factor (SDF-1α) and is a principal coreceptor for human …

Integral membrane G protein-coupled receptors (GPCRs) compose the single most prolific
class of drug targets, yet significant functional and structural questions remain unanswered …

Considerable evidence suggests that G-protein-coupled receptors form homomeric and
heteromeric dimersin vivo. Unraveling the structural mechanism for cross-talk between …